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Gene & Protein in Disease Signatures construction strategies for TC
References Xu et al., 2021 [39] Huang et al., 2021 [34] Ruchong et al., 2021 [36] Ren et al., 2021 [35] Ruiz et al., 2020 [20] Yu et al., 2021 Zhong et al., 2020 [40] Wu et al., 2020 [38] Wu et al., 2019 [19] (Cont’d...)
Multivariate Cox analysis P‑value HR (95% CI) P=6.37e-05 7.26 (2.75 – 19.17) P<0.001 5.065 (2.215 – 11.584) 2.64 (1.03 – 6.77) P=0.001 1.008 (1.003 – 1.012) P<0.0001 5.39 (2.45 – 11.85) P=0.0077 3.01 (1.34 – 6.76)
Univariate Cox analysis P‑value HR (95% CI) P=3.16e-07 7.27 (3.4-15.5) P<0.001 5.015 (2.330 – 10.793) P=0.002 2.81 P<0.001 1.007 (1.003 – 1.011) P<0.0001 6.9 (3.45 – 13.79) P=0.0004 4.15 (1.88 – 9.16)
Signature outcome Unfavorable Unfavorable Unfavorable Unfavorable Unfavorable Unfavorable Unfavorable Unfavorable Unfavorable
AUC of the ROC curve AUC at 1-, 3-, and 5-years OS: 0.994, 0.987, and 1 AUC at 1-, 3-, and 5-year DFS: 0.804, 0.772, and 0.72 AUC at 1-, 3-, and 5-year DFS: 0.716, 0.705, and 0.681 AUCs for 1-, 3-, and 5-year OS: 0.81, 0.67, and 0.72 0.86 0.729 AUC of 3- and 5-year survival: 0.937 and0.925 AUC of 1-, 2-, 3-, 4-, and 5-year PFI: 0.6623, 0.6740, 0.6791, 0.6656, and 0.6484
Table 1. The prognostic signatures of TC patients are summarized in strategy 1
Survival curve P‑value P=4e-04 P=4.613e-06 P=7.427e-14 P=0.00087 P=0.001 P=0.01798 P=0.0000259 P<0.0001 P=0.0001
Survival event OS DFS DFS OS DFS OS OS PFI PFI
Signature ENTPD1, PAPSS2, LRRC75A, KIAA1211L, ADRA1B, PCOLCE2, HSPA6, PDLIM3, MPL, ANKRD37, LOXL2, ADAM22, SMIM10L2B, CTXND1, NECAB1, LBX2, ITPKA, F2RL2, MAST1, SIGLEC11, and EFNB3 MMP9, AKR1C1, PLA2G2E, CARTPT, and SLC5A1 TENM1, FN1, APOD, F12, and BTNL8 CDH3, CTGF, CYR61, OGN, FGF13, and CHRDL1 a 25-gene signature FTO, RBM15, and KIAA1429 ADRA1B, RIPPLY3, PCOLCE, TEKT1, and SALL3 CLCNKB, FXBO27, FXYD6, RIMS2,
Signature type mRNA mRNA mRNA mRNA mRNA mRNA mRNA mRNA mRNA
Author Lei Xu, et al., 2021 Yanyi Huang, et al., 2021 Ruchong Pan, et al., 2021 He Ren, et al., 2021 Emmanuelle Ruiz, et al., 2020 Zhihao Yu, et al., 2021 Linkun Zhong, et al., 2020 Mengwei Wu, et al., 2020 Mengwei Wu, et al., 2019
Volume 2 Issue 3 (2023) 5 https://doi.org/10.36922/gpd.1138
