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Gene & Protein in Disease Signatures construction strategies for TC
References Zhang et al., 2019 [43] Li et al., 2017 [41] Luo et al., 2017 [42] You et al., 2018 [33] Liu et al., 2018 [11] Chengfeng et al., 2019 [44] Teng et al., 2018 [21] Saftencu et al., 2019 [37] Zhang et al., 2020 [55] Zhang et al., 2020 [55] (Cont’d...)
Multivariate Cox analysis P‑value HR (95% CI) P=0.034 1.131 (1.01 – 1.267) P=0.008 7.092 (1.667 – 30.179) P=0.034 0.11 (0.014 – 0.845) P=0.0338 9.28 (1.19 – 72.58)
Univariate Cox analysis P‑value HR (95% CI) P=0.004 1.094 (1.028 – 1.163) P<0.001 8.592 (2.878 – 25.651) P=0.004 19.091 (2.519 – 144.674) P<0.05 4.39 (1.24 – 15.57) P=0.0172 11.81 (1.55 – 89.93)
Signature outcome Unfavorable Unfavorable Unfavorable Unfavorable Unfavorable Unfavorable Unfavorable Unfavorable
AUC of the ROC curve 0.862 0.833 0.739 0.784 0.886 AUC values for predicting 5-year and 10-year survival: 0.894 and 0.957 AUC values for predicting 5-year and 10-year survival: 0.843 and 0.89
Survival curve P‑value P=0.0001627 P=0.016 P<0.001 P=0.022 P=0.003 P=0.00006 P=0.012 P=0.00244
Survival event OS OS OS OS OS OS DFS DFS OS OS
DOCK9-DT, LINC00900, AC079630.2, CRNDE, and CTD-2171N6.1 PRSS3P2, KRTAP5-AS1, Has-miR-181a-2-3p and hsa‐mir‐6730, hsa‐ mir‐196a‐2, and hsa‐ ITGA10 and MSLN Lnc2mi1m2 (DIO3OS, MLIP-AS1, has-mir-96, Lnc5m4 (AC006487.1, DGUOK-AS1, TLR8-AS1, AC024563.1, ALPL, GALNT7, ARMCX6,
Signature C8orf34-AS1, LINC01736, ATP2C2-AS1, FAM111A-DT, LINC02550, and LINC01896 RP11-536N17.1, RP11-508M8.1, AC026150.8, and CTD-2139B15.2 and PWAR5 has-miR-138-1-3p Has-mir‐6843, mir‐206 HIGD1B, SDPR, PACERR, and CYP4A22-AS1 CADM2, TPPP) AC022148.1, IL11)
Table 1. (Continued) Signature Author type lncRNA Yun Zhang, et al., 2019 lncRNA Qiuying Li, et al., 2017 a lncRNA Yihuan Luo, et al., 2017 lncRNA Xin You, et al., 2018 miRNA Tong Liu, et al., 2018 miRNA Chengfeng Xiong, et al., 2019 mRNA/ Huajing Teng, lncRNA et al., 2018 mRNA/ Mihai Saftencu, miRNA et al., 2019 mRNA/ Xiaoping Li, miRNA/ et al., 2020 lncRNA mRNA/ lncRNA
Volume 2 Issue 3 (2023) 6 https://doi.org/10.36922/gpd.1138
