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Gene & Protein in Disease Signatures construction strategies for TC
References Wang et al., 2020 [66] Lv et al., 2020 [47] Chen et al., 2021 [79] Hou et al., 2020 [49] Xu et al., 2020 [48] (Cont’d...)
Multivariate Cox regression analysis P‑value 95% HR CI P = 0.04 1.000 – 1.001 1.003 P < 0.001 1.287 – 1.602 1.995 P = 0.022 1.001 – 1.01 1.019 P = 0.006 1.265 – 2.233 3.942
Univariate Cox regression analysis P‑value 95% HR CI P = 0.047 1.000 – 1.001 1.003 P < 0.001 1.142 – 1.344 1.582 P < 0.001 1.005 − 1.013 1.021 P < 0.001 3.212 – 5.058 7.963
AUC of the ROC curve 0.817 0.836 1-, 3- and 5-year AUCs: 0.73, 0.71 and 0.76 0.716 0.747
Risk score Risk score = (0.390 * MTHFD1) + (0.167 * IGF2BP2) + (0.152 * GSTM4) + (−0.133 * STT3A) Risk score = (0.331) * Expression value of RDH5 + (0.165) * Expression value of TREM1 + (0.017) * Expression value of BIRC7 + (0.016) * Expression value of SLC26A7 Risk score = (3.23) * β value (ALDOC) + (2.98) * β value (C14orf62)+ (−8.96) * β value (DVL1) + (18.23) * β value (PTPRC) Risk score = (1.139 * RBM15)
Survival curve P‑value Cut‑off P = The 0.00008166 median risk score P < 0.001 The median of risk scores P = 0.016 The median of risk scores P = 0.01541 The median risk score P = The 0.0004741 median risk score
Table 3. The prognostic signatures of TC are summarized in strategy 3
Survival event PFS OS OS OS PFS DFS
Signatures outcome Unfavorable Unfavorable Unfavorable Unfavorable Unfavorable
Signatures IGF2BP2, STT3A, MTHFD1, and GSTM4 RDH5, TREM1, BIRC7, and SLC26A7 ALDOC, C14orf62, DVL1 and PTPRC RBM15 KIAA1429 FTO WTAP, ZC3H13, HNRNPC and ALKBH5 21 DNA methylation probes**
Signatures type m6A RNA methylation regulators Methylation -driven genes Methylation -driven genes m6A RNA methylation regulators m6A RNA methylation regulators DNA methylation probes
Pathological type PTC TC TC PTC DTC WDTC
Authors Xinyi Wang, et al., 2020 Liting Lv, et al., 2020 Zhiwei Chen, et al., 2021 Jianzhong Hou, et al., 2020 Nizhen Xu, et al., 2020 Mariana Reis, et al., 2017
Volume 2 Issue 3 (2023) 11 https://doi.org/10.36922/gpd.1138
