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Gene & Protein in Disease Stem cell-based antimicrobial therapy

of antimicrobial therapies based on stem cells . A clinical and the microenvironment of the site of infection. The
[73]
trial of phase I was executed to assess the safety and production of synthetic AMPs by MSCs may not be uniform
effectiveness of intravenous infusion of allogeneic MSCs across all cells and may necessitate meticulous genetic
in patients diagnosed with severe sepsis. The research engineering techniques. The introduction of genetically
discovered that the infusion of MSCs was deemed safe and modified cells into a patient’s body may trigger an immune
well-tolerated and was linked to enhanced survival rates response or result in unwanted side effects. Although stem
and decreased organ dysfunction. Another example of a cells can be guided to migrate toward specific regions,
clinical study is the use of neural progenitor cells produced ensuring that they solely target infected tissues and not
from human embryonic stem cells to treat herpes simplex healthy ones poses a challenge. The long-term safety of
virus (HSV)-induced encephalitis . Individuals with using engineered stem cells and synthetic peptides in
[74]
HSV encephalitis were given intracerebral injections of humans is still under investigation . The development
[77]
neural progenitor cells generated from human embryonic and implementation of this approach necessitate advanced
stem cells during a phase I clinical trial. The study showed biotechnological processes and rigorous safety evaluations.
that the treatment was safe, well-tolerated, and associated The genetic alteration of stem cells raises ethical concerns
with improved neurological outcomes. Case studies that must be thoughtfully addressed.
and examples of preclinical and clinical investigations Furthermore, researchers are investigating the potential
illustrate the promise of stem cell-based antimicrobial of stem cells in the creation of immunizations for contagious
therapy as unique and successful treatments for infections illnesses. Stem cells have the ability to produce large amounts
that are resistant to conventional antibiotics. Through of viral or bacterial antigens, evoking the host immune
the examination of diverse stem cell varieties, modes of response, and promoting the development of protective
delivery, and antimicrobial objectives, it is possible to immunity against pathogenic micro-organisms . In
[78]
devise customized remedies for different infection types addition, ongoing research investigates the ability of stem
and promote the development and application of stem cell- cells to regulate the microbiome, which is the collection
based antimicrobial interventions.
of microorganisms that inhabit the human body. The
The utilization of stem cell-based antimicrobial occurrence of dysbiosis, which refers to an imbalance in the
therapies is a burgeoning field that shows great potential microbiome’s composition, has been linked to numerous
for the creation of innovative and efficacious remedies infectious and inflammatory diseases. Stem cells have the
for infections resistant to conventional antibiotics. The potential to modulate the microbiome by promoting the
latest developments in stem cell research have created proliferation of beneficial micro-organisms and inhibiting
new prospects for the creation of specific antimicrobial the proliferation of harmful microorganisms. Targeted
treatments through the utilization of stem cells . An antimicrobial therapies utilizing stem cells represent a
[75]
emerging prospect involves the utilization of genetically potential avenue for the development of innovative and
modified stem cells to manifest AMPs or other elements effective therapeutics for antibiotic-resistant infections.
that can amplify the antimicrobial characteristics of stem The utilization of stem cells’ distinctive characteristics can
cells. Through the expression of these factors, stem cells facilitate the creation of customized remedies for diverse
may enhance their efficacy in managing infections and categories of infections and promote the development of
facilitating tissue regeneration. An additional developing stem cell-oriented antimicrobial therapies.
prospect pertains to the utilization of stem cells for
administering precise antimicrobial agents to the specific 6. Conclusion
location of infection. It is possible to manipulate stem cells The area of research pertaining to the potential of stem cells
to secrete antimicrobial agents on detection of particular for targeted antimicrobial treatment is a rapidly evolving
stimuli, such as the existence of bacterial or viral antigens. and exciting field. Due to their ability to differentiate
The precise administration of antimicrobial agents can into specialized cellular lineages and control the immune
enhance their efficacy and mitigate the potential for non- system’s response, stem cells have unique properties that
specific impacts . make them particularly well-suited for treating infectious
[76]
Various types of stem cells possess differing capabilities diseases. The development of stem cell-based antimicrobial
in generating and distributing antimicrobial agents. One treatments has the potential to revolutionize the way
example is MSCs, which have been extensively researched we treat infections, despite the existence of a number of
for their immunomodulatory properties and potential issues that need to be addressed, such as the creation of
to generate AMPs. However, the effectiveness of the standardized procedures for cell isolation, expansion, and
antimicrobial effect may differ depending on the specific delivery. In response to the escalating antibiotic resistance
type of AMP generated, the concentration of the peptide, crisis, development of novel and targeted therapeutic

Volume 2 Issue 4 (2023) 9 https://doi.org/10.36922/gpd.1230