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Gene & Protein in Disease A pyroptosis-related gene signature in myeloma

A B C

D E

F G H

Figure 8. In vitro validation of the expression of 9 PRGs in MM cells treated with the pyroptosis-inducing agent etoposide. (A-H) The mRNA expressions
of CHMP2A (A), CHMP3 (B), NOD2 (C), PLCG1 (D), FOXO3 (E), CASP3 (F), CASP8 (G), and CHMP6 (H) in the MM cells treated with varying
concentrations of etoposide.
Abbreviations: MM: Multiple myeloma; PRGs: Pyroptosis-related genes.

4,5-bisphosphate (PIP2) into diacylglycerol (DAG) and understanding of the roles of pyroptosis in MM prognosis,
inositol trisphosphate (IP3), both of which are critical in thereby facilitating the development of precision medicine.
controlling inflammasome activation and pyroptosis.
46
However, given that MM cells undergo pyroptosis mainly Acknowledgments
through GSDME- but not GSDMD-mediated pathway, the None.
specific roles of these genes in MM cell pyroptosis should
be further investigated. Funding

5. Conclusion This project was partly supported by the National Key Research
and Development Program of China (#2022YFC2705003),
The present study establishes a novel PRG-based National Natural Science Foundation of China (#82170176),
independent prognostic model that is powerful to predict and Guangzhou Medical University Discipline Construction
the overall survival of MM patients and effective for Funds (Basic Medicine) (#JCXKJS2022A05).
distinguishing among MM patients with different disease
risk profile. However, our PRG signature set does not Conflict of interest
encompass genes related to karyotype or mutations in the Xinliang Mao is the Editorial Board Member of this
IPSS system, making it a novel and effective model for journal but was not in any way involved in the editorial
stratifying MM patients and predicting prognosis, that is and peer-review process conducted for this paper, directly
not governed by the current IPSS system’s classification or indirectly. Separately, other authors declared that they
and not restricted by karyotype profiles. Moreover, we also have no known competing financial interests or personal
found several key genes that might play key roles in MM cell relationships that could have influenced the work reported
pyroptosis. Our future work will continue to deepen our in this paper.

Volume 3 Issue 4 (2024) 13 doi: 10.36922/gpd.4534