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Gene & Protein in Disease Drugs and immune infiltration in IPF

Funding doi: 10.1164/rccm.2009-040GL

The work was supported by the Beijing Municipal Public 2. Raghu G, Weycker D, Edelsberg J, Bradford WZ, Oster G.
Welfare Development and Reform Pilot Project for Medical Incidence and prevalence of idiopathic pulmonary fibrosis.
Research Institutes (PWD&RPP-MRI; Project Number: Am J Respir Crit Care Med. 2006;174(7):810-816.
JYY2023-14). doi: 10.1164/rccm.200602-163OC

Conflict of interest 3. Richeldi L, Collard HR, Jones MG. Idiopathic pulmonary
fibrosis. Lancet. 2017;389(10082):1941-1952.
Umair Ali Khan Saddozai serves as the Editorial Board doi: 10.1016/S0140-6736(17)30866-8
Member of the journal but was not in any way involved 4. Wuyts WA, Agostini C, Antoniou KM, et al. The
in the editorial and peer-review process conducted for pathogenesis of pulmonary fibrosis: A moving target. Eur
this paper, directly or indirectly. Separately, the authors Respir J. 2013;41(5):1207-1218.
declare that the research was conducted in the absence of
any commercial or financial relationships that could be doi: 10.1183/09031936.00073012
construed as a potential conflict of interest. 5. Hwang HW, Mendell JT. MicroRNAs in cell proliferation, cell
death, and tumorigenesis. Br J Cancer 2006;94(6):776-780.
Author contributions
doi: 10.1038/sj.bjc.6603023
Conceptualization: Jinghui Wang, Zhendong Lu 6. O’Reilly S. MicroRNAs in fibrosis: Opportunities and
Formal analysis: Zhendong Lu, Siyun Fu, Lingqin Zhu, challenges. Arthritis Res Ther. 2016;18:11.
Umair Ali Khan Saddozai
Investigation: Zhendong Lu, Umair Ali Khan Saddozai doi: 10.1186/s13075-016-0929-x
Methodology: Jinghui Wang, Zhendong Lu, Umair Ali 7. Tzouvelekis A, Kaminski N. Epigenetics in idiopathic
Khan Saddozai pulmonary fibrosis. Biochem Cell Biol. 2015, 93(2):159-170.
Writing–original draft: Zhendong Lu doi: 10.1139/bcb-2014-0126
Writing–review & editing: Zhendong Lu, Umair Ali Khan 8. Misharin AV, Morales-Nebreda L, Reyfman PA, et al.
Saddozai
Monocyte-derived alveolar macrophages drive lung fibrosis
Ethics approval and consent to participate and persist in the lung over the life span. J Exp Med.
2017;214(8):2387-2404.
This study is based on published data and does not involve doi: 10.1084/jem.20162152
the collection of new human or animal data. All data
used in this study are sourced from previously published 9. Hams E, Armstrong ME, Barlow JL, et al. IL-25 and type 2
research articles and publicly available data sources, and innate lymphoid cells induce pulmonary fibrosis. Proc Natl
Acad Sci U S A. 2014;111(1):367-372.
no direct patient contact or intervention was involved in
the study. Therefore, ethical approval is not required for doi: 10.1073/pnas.1315854111
this study. 10. Langfelder P, Horvath S. WGCNA: An R package for
weighted correlation network analysis. BMC Bioinform.
Consent for publication 2008;9:559.
Not applicable. doi: 10.1186/1471-2105-9-559.

Availability of data 11. Shannon P, Markiel A, Ozier O, et al. Cytoscape: A software
environment for integrated models of biomolecular
The original contributions presented in this study have interaction networks. Genome Res. 2003;13(11):2498-2504.
been included in the article. The raw data designed for doi: 10.1101/gr.1239303
this study, GSE2052, GSE53845, and GSE110147, can be
obtained from the GEO database. For further inquiries, 12. Huang HY, Lin YC, Li J, et al. miRTarBase 2020: Updates to
please contact the corresponding authors. the experimentally validated microRNA-target interaction
database. Nucleic Acids Res. 2020;48(D1):D148-D154.
References doi: 10.1093/nar/gkz896
1. Raghu G, Collard HR, Egan JJ, et al. An official ATS/ERS/ 13. Yang JH, Li JH, Shao P, Zhou H, Chen YQ, Qu LH. starBase:
JRS/ALAT statement: Idiopathic pulmonary fibrosis: A database for exploring microRNA-mRNA interaction
Evidence-based guidelines for diagnosis and management. maps from Argonaute CLIP-Seq and Degradome-Seq data.
Am J Respir Crit Care Med. 2011;183(6):788-824. Nucleic Acids Res. 2011;39(Database issue):D202-D209.

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