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Gene & Protein in Disease                                  A prediction on how Epimedii herba treat periodontitis



            TNF, IL6, TP53, VEGFA, IL1B, CASP3, PTGS2, MMP9,   References
            and  ESR1. These ingredients  play  an anti-inflammatory   1.   Slots J. Periodontitis: Facts, fallacies and the future.
            role, promote the regeneration of periodontal tissue, and   Periodontol 2000. 2017;75(1):7-23.
            provide a new drug alternative for the clinical treatment of
            periodontitis. Nevertheless, there is still a long way to go      doi: 10.1111/prd.12221
            before the clinical application of these drugs, and further   2.   Graves DT, Correa JD, Silva TA. the oral microbiota is
            laboratory research and clinical trials are warranted.  modified by systemic diseases. J Dent Res. 2019;98(2):148-156.

            Acknowledgments                                       doi: 10.1177/0022034518805739
                                                               3.   Qin H, Li G, Xu X, et al. The role of oral microbiome in
            None.
                                                                  periodontitis under diabetes mellitus.  J  Oral Microbiol.
            Funding                                               2022;14(1):2078031.
                                                                  doi: 10.1080/20002297.2022.2078031
            This work was supported by grants from the Foundation
            of Science and Technology Department of Henan      4.   Sanz M,  Del Castillo  AM, Jepsen S,  et al. Periodontitis
            Province, China (no.  212102310103); Natural Science   and cardiovascular diseases: Consensus report.  J  Clin
            Foundation of Education Department of Henan           Periodontol. 2020;47(3):268-288.
            Province, China (no.  21A320004); Foundation of the      doi: 10.1111/jcpe.13189
            National Health Commission of Henan Province, China   5.   De Molon RS, Rossa C Jr., Thurlings RM, Cirelli JA,
            (no. Wjlx2020017); Foundation of the Educational      Koenders MI. Linkage of periodontitis and rheumatoid
            Administration Department of Henan University, China   arthritis: Current evidence and potential biological
            (no. HDXJJG2020-83); and Foundation of Science &      interactions. Int J Mol Sci. 2019;20(18):4541.
            Technology Department of Kaifeng City, Henan Province,
            China (no. 2203015).                                  doi: 10.3390/ijms20184541
                                                               6.   Kwon T, Lamster IB,  Levin L.  Current concepts in the
            Conflict of interest                                  management of periodontitis. Int Dent J. 2021;71(6):462-476.
            Yuankun Zhai is an Editorial Board Member of this      doi: 10.1111/idj.12630
            journal but was not in any way involved in the editorial   7.   Bessa LJ, Botelho J, Machado V, Alves R, Mendes JJ.
            and peer-review process conducted for this paper, directly   Managing oral health in the context of antimicrobial
            or indirectly. Separately, other authors declared that they   resistance. Int J Environ Res Public Health. 2022;9(24):16448
            have no known competing financial interests or personal
            relationships that could have influenced the work reported      doi: 10.3390/ijerph192416448
            in this paper.                                     8.   Xu H, Zhou S, Quet R,  et al. Icariin prevents oestrogen
                                                                  deficiency-induced alveolar bone loss through promoting
            Author contributions                                  osteogenesis via STAT3. Cell Prolif. 2020;53(2):e12743.
            Conceptualization: Yuankun Zhai                       doi: 10.1111/cpr.12743
            Investigation: Junhan Wan, Mingzhen Yang           9.   Wu J, Zhou J, Chen X, et al. Attenuation of LPS-induced
            Methodology: Junhan Wan, Yingjie Zhu                  inflammation by ICT, a derivate of icariin, via inhibition of
            Writing – original draft: Junhan Wan                  the CD14/TLR4 signaling pathway in human monocytes.
            Writing – review & editing:  Wenwen Wang, Ningli Li,   Int Immunopharmacol. 2012;12(1):74-79.
               Yuankun Zhai                                       doi: 10.1016/j.intimp.2011.10.015
            Ethics approval and consent to participate         10.  Sun S, Liu L, Tian X, et al. Icariin attenuates high glucose-
                                                                  induced apoptosis, oxidative stress, and inflammation in
            Not applicable.                                       human umbilical venous endothelial cells.  Planta Med.
            Consent for publication                               2019;85(6):473-482.
                                                                  doi: 10.1055/a-0837-0975
            Not applicable.
                                                               11.  Ma H, He X, Yang Y, Li M, Hao D, Jia Z. The genus
            Availability of data                                  epimedium: An ethnopharmacological and phytochemical
                                                                  review. J Ethnopharmacol. 2011;134(3):519-541.
            The datasets used and analyzed in the current study are
            available from the corresponding author upon reasonable      doi: 10.1016/j.jep.2011.01.001
            request.                                           12.  Wang S, Ma J, Zeng Y,  et al. Icariin, an up-and-coming


            Volume 3 Issue 4 (2024)                         12                              doi: 10.36922/gpd.4427
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