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Gene & Protein in Disease A prediction on how Epimedii herba treat periodontitis
TNF, IL6, TP53, VEGFA, IL1B, CASP3, PTGS2, MMP9, References
and ESR1. These ingredients play an anti-inflammatory 1. Slots J. Periodontitis: Facts, fallacies and the future.
role, promote the regeneration of periodontal tissue, and Periodontol 2000. 2017;75(1):7-23.
provide a new drug alternative for the clinical treatment of
periodontitis. Nevertheless, there is still a long way to go doi: 10.1111/prd.12221
before the clinical application of these drugs, and further 2. Graves DT, Correa JD, Silva TA. the oral microbiota is
laboratory research and clinical trials are warranted. modified by systemic diseases. J Dent Res. 2019;98(2):148-156.
Acknowledgments doi: 10.1177/0022034518805739
3. Qin H, Li G, Xu X, et al. The role of oral microbiome in
None.
periodontitis under diabetes mellitus. J Oral Microbiol.
Funding 2022;14(1):2078031.
doi: 10.1080/20002297.2022.2078031
This work was supported by grants from the Foundation
of Science and Technology Department of Henan 4. Sanz M, Del Castillo AM, Jepsen S, et al. Periodontitis
Province, China (no. 212102310103); Natural Science and cardiovascular diseases: Consensus report. J Clin
Foundation of Education Department of Henan Periodontol. 2020;47(3):268-288.
Province, China (no. 21A320004); Foundation of the doi: 10.1111/jcpe.13189
National Health Commission of Henan Province, China 5. De Molon RS, Rossa C Jr., Thurlings RM, Cirelli JA,
(no. Wjlx2020017); Foundation of the Educational Koenders MI. Linkage of periodontitis and rheumatoid
Administration Department of Henan University, China arthritis: Current evidence and potential biological
(no. HDXJJG2020-83); and Foundation of Science & interactions. Int J Mol Sci. 2019;20(18):4541.
Technology Department of Kaifeng City, Henan Province,
China (no. 2203015). doi: 10.3390/ijms20184541
6. Kwon T, Lamster IB, Levin L. Current concepts in the
Conflict of interest management of periodontitis. Int Dent J. 2021;71(6):462-476.
Yuankun Zhai is an Editorial Board Member of this doi: 10.1111/idj.12630
journal but was not in any way involved in the editorial 7. Bessa LJ, Botelho J, Machado V, Alves R, Mendes JJ.
and peer-review process conducted for this paper, directly Managing oral health in the context of antimicrobial
or indirectly. Separately, other authors declared that they resistance. Int J Environ Res Public Health. 2022;9(24):16448
have no known competing financial interests or personal
relationships that could have influenced the work reported doi: 10.3390/ijerph192416448
in this paper. 8. Xu H, Zhou S, Quet R, et al. Icariin prevents oestrogen
deficiency-induced alveolar bone loss through promoting
Author contributions osteogenesis via STAT3. Cell Prolif. 2020;53(2):e12743.
Conceptualization: Yuankun Zhai doi: 10.1111/cpr.12743
Investigation: Junhan Wan, Mingzhen Yang 9. Wu J, Zhou J, Chen X, et al. Attenuation of LPS-induced
Methodology: Junhan Wan, Yingjie Zhu inflammation by ICT, a derivate of icariin, via inhibition of
Writing – original draft: Junhan Wan the CD14/TLR4 signaling pathway in human monocytes.
Writing – review & editing: Wenwen Wang, Ningli Li, Int Immunopharmacol. 2012;12(1):74-79.
Yuankun Zhai doi: 10.1016/j.intimp.2011.10.015
Ethics approval and consent to participate 10. Sun S, Liu L, Tian X, et al. Icariin attenuates high glucose-
induced apoptosis, oxidative stress, and inflammation in
Not applicable. human umbilical venous endothelial cells. Planta Med.
Consent for publication 2019;85(6):473-482.
doi: 10.1055/a-0837-0975
Not applicable.
11. Ma H, He X, Yang Y, Li M, Hao D, Jia Z. The genus
Availability of data epimedium: An ethnopharmacological and phytochemical
review. J Ethnopharmacol. 2011;134(3):519-541.
The datasets used and analyzed in the current study are
available from the corresponding author upon reasonable doi: 10.1016/j.jep.2011.01.001
request. 12. Wang S, Ma J, Zeng Y, et al. Icariin, an up-and-coming
Volume 3 Issue 4 (2024) 12 doi: 10.36922/gpd.4427

