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Gene & Protein in Disease A prediction on how Epimedii herba treat periodontitis

Figure 3. Epimedii herba (EH) ingredient–target interaction network. Pink nodes represent the active ingredients of EH, and green nodes represent the
potential targets of EH

not only the LPS-induced acute inflammatory response in protecting tissue cells. The anti-inflammatory activities
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involving the PI3K/Akt and nuclear factor-kappa B of these components have extensively demonstrated the
(NF-κB) signaling pathway but also the interleukin- potential of EH for treating periodontitis.
1β-induced inflammatory response in human nucleus
pulposus cells. 31,32 Moreover, kaempferol, a polyphenol Network pharmacology analyses showed that the
from Epimedium, has been found to exert potential antiperiodontitis activity of psoralen was associated with
anti-inflammatory effects. Kaempferol has been used several key targets, such as AKT1, TNF, and MMP9.
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to treat several diseases with its multiple biological AKT1, also known as protein kinase β, is closely related
properties, including antitumor, anti-inflammatory, and to cell proliferation and can protect the endothelial barrier
antioxidant activities; it can also help improve the body’s and prevent abnormal vascular permeability, which may
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antioxidant defense against free radicals; regulate cell exhibit some correlation with the remission of periodontal
signaling pathways related to apoptosis, angiogenesis, and disease. 35,36 TNF is an active cytokine that can induce an
inflammation; maintain normal cell vitality; and play a role inflammatory response and cell death. 37

Volume 3 Issue 4 (2024) 7 doi: 10.36922/gpd.4427