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Gene & Protein in Disease                                  A prediction on how Epimedii herba treat periodontitis



               bioactive compound against neurological diseases: Network   free  energy  calculations with GROMACS.  J  Chem Theory
               pharmacology-based study and literature review. Drug Des   Comput. 2021;17(10):6281-6291.
               Devel Ther. 2021;15:3619-3641.
                                                                  doi: 10.1021/acs.jctc.1c00645
               doi: 10.2147/DDDT.S310686
                                                               24.  Poli  G,  Granchi  C, Rizzolio  F, Tuccinardi  T.  Application
            13.  Sze SC, Tong Y, Ng TB, Cheng CL, Cheung HP. Herba   of MM-PBSA methods in virtual screening.  Molecules.
               Epimedii: Anti-oxidative properties and its medical   2020;25(8):1971.
               implications. Molecules. 2010;15(11):7861-7870.
                                                                  doi: 10.3390/molecules25081971
               doi: 10.3390/molecules15117861
                                                               25.  Di Stefano M, Polizzi A, Santonocito S, Romano A, Lombardi T,
            14.  He W, Sun H, Yang B, Zhang D, Kabelitz D.        Isola G. Impact of oral microbiome in periodontal health
               Immunoregulatory effects of the herba epimediia glycoside   and  periodontitis:  A  critical  review  on  prevention  and
               icariin. Arzneimittelforschung. 1995;45(8):910-913.  treatment. Int J Mol Sci. 2022;23(9):5142.
            15.  Verma A, Aggarwal K, Agrawal R, Pradhan K, Goyal A.      doi: 10.3390/ijms23095142
               Molecular mechanisms regulating the pharmacological
               actions of icariin with special focus on PI3K-AKT and Nrf-2   26.  Hajishengallis G, Darveau RP, Curtis MA. The keystone-
               signaling pathways. Mol Biol Rep. 2022;49(9):9023-9032.  pathogen hypothesis. Nat Rev Microbiol. 2012;10(10):717-725.
               doi: 10.1007/s11033-022-07778-3                    doi: 10.1038/nrmicro2873
            16.  Bi Z, Zhang W, Yan X. Anti-inflammatory and   27.  Liu X, Niu Y, Xie W, Wei D, Du Q. Tanshinone IIA promotes
               immunoregulatory effects of icariin and icaritin.  Biomed   osteogenic differentiation of human periodontal ligament
               Pharmacother. 2022;151:113180.                     stem cells via ERK1/2-dependent Runx2 induction.  Am J
                                                                  Transl Res. 2019;11(1):340-350.
               doi: 10.1016/j.biopha.2022.113180
                                                               28.  Cao CF, Sun XP. Herbal medicine for periodontal diseases.
            17.  Alam W, Khan H, Shah MA, Cauli O, Saso L. Kaempferol   Int Dent J. 1998;48(3 Suppl 1):316-322.
               as a dietary anti-inflammatory agent: Current therapeutic
               standing. Molecules. 2020;25(18):4073.             doi: 10.1111/j.1875-595x.1998.tb00722.x
               doi: 10.3390/molecules25184073                  29.  Chan Y, Lai CH, Yang HW, Lin YY, Chan CH. The evaluation
                                                                  of Chinese herbal medicine effectiveness on periodontal
            18.  Zheng X, Dong Z, Liang Z, et al. Photothermally responsive   pathogens. Am J Chin Med. 2003;31(5):751-761.
               icariin and carbon nanofiber modified hydrogels for
               the treatment of  periodontitis.  Front  Bioeng  Biotechnol.      doi: 10.1142/S0192415X03001417
               2023;11:1207011.                                30.  Shen R, Wang JH. The effect of icariin on immunity
               doi: 10.3389/fbioe.2023.1207011                    and its potential application.  Am J Clin Exp Immunol.
                                                                  2018;7(3):50-56.
            19.  Zhang X, Han N, Li G,  et al. Local icariin application
               enhanced periodontal tissue regeneration and relieved local   31.  Xu CQ, Liu BJ, Wu JF, et al. Icariin attenuates LPS-induced
               inflammation in a minipig model of periodontitis. Int J Oral   acute inflammatory responses: Involvement of PI3K/
               Sci. 2018;10(2):19.                                Akt and NF-kappaB signaling pathway.  Eur J Pharmacol.
                                                                  2010;642(1-3):146-153.
               doi: 10.1038/s41368-018-0020-3
                                                                  doi: 10.1016/j.ejphar.2010.05.012
            20.  Han Y, Sun H, Zhang A, Yan G, Wang XJ. Chinmedomics, a
               new strategy for evaluating the therapeutic efficacy of herbal   32.  Hua W, Zhang Y, Wu X, et al. Icariin attenuates interleukin-
               medicines. Pharmacol Ther. 2020;216:107680.        1beta-induced inflammatory response in human nucleus
                                                                  pulposus cells. Curr Pharm Des. 2018;23(39):6071-6078.
               doi: 10.1016/j.pharmthera.2020.107680
                                                                  doi: 10.2174/1381612823666170615112158
            21.  Lou Y, Ma M, Jiang Y, et al. Ferroptosis: A new strategy for
               traditional Chinese medicine treatment of stroke.  Biomed   33.  Devi KP, Malar DJ, Nabavi SF,  et al. Kaempferol and
               Pharmacother. 2022;156:113806.                     inflammation: From chemistry to medicine. Pharmacol Res.
                                                                  2015;99:1-10.
               doi: 10.1016/j.biopha.2022.113806
                                                                  doi: 10.1016/j.phrs.2015.05.002
            22.  Zhang  Z,  Zheng  Y,  Bian  X,  et al.  Identification  of  key
               genes and pathways associated with oxidative stress in   34.  Chen AY, Chen YC. A  review of the dietary flavonoid,
               periodontitis. Oxid Med Cell Longev. 2022;2022:9728172.  kaempferol on human health and cancer chemoprevention.
                                                                  Food Chem. 2013;138(4):2099-2107.
               doi: 10.1155/2022/9728172
                                                                  doi: 10.1016/j.foodchem.2012.11.139
            23.  Valdes-Tresanco MS, Valdés-Tresanco ME, Valiente PA,
               Moreno E. gmx_MMPBSA: A new tool to perform end-state   35.  Mundi PS, Sachdev J, McCourt C, Kalinsky K. AKT in


            Volume 3 Issue 4 (2024)                         13                              doi: 10.36922/gpd.4427
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