Page 33 - GPD-4-2

Gene & Protein in Disease lncRNAs dysregulation in diabetes and its complications

in renal-biopsy specimens from patients with persistent 187 single nucleotide polymorphisms (SNPs) among 41
glomerular nephritis. Lancet. 1968;292(7564):363-366. candidate genes for ischemic heart disease in the Japanese
population. Hum Genet. 2000;106:288-292.
doi: 10.1016/s0140-6736(68)90589-8
doi: 10.1007/s004390051039
47. Mourtada-Maarabouni M, Williams GT. Role of GAS5
noncoding RNA in mediating the effects of rapamycin and 58. Ishii N, Ozaki K, Sato H, et al. Identification of a novel
its analogues on mantle cell lymphoma cells. Clin Lymphoma non-coding RNA, MIAT, that confers risk of myocardial
Myeloma Leuk. 2014;14(6):468-473. infarction. J Hum Genet. 2006;51:1087-1099.
doi: 10.1016/j.clml.2014.02.011 doi: 10.1007/s10038-006-0070-9
48. Thomas MC. Epigenetic mechanisms in diabetic kidney 59. Yan B, Yao J, Liu JY, et al. lncRNA-MIAT regulates
disease. Curr Diab Rep. 2016;16:31. microvascular dysfunction by functioning as a competing
endogenous RNA. Circ Res. 2015;116(7):1143-1156.
doi: 10.1007/s11892-016-0723-9
doi: 10.1161/CIRCRESAHA.116.305510
49. Li Y, Xu K, Xu K, Chen S, Cao Y, Zhan H. Roles of identified
long noncoding RNA in diabetic nephropathy. J Diabetes 60. Zhang J, Chen M, Chen J, et al. Long non-coding RNA
Res. 2019;2019:5383010. MIAT acts as a biomarker in diabetic retinopathy by
absorbing miR-29b and regulating cell apoptosis. Biosci
doi: 10.1155/2019/5383010 Rep. 2017;37(2):BSR20170036.
50. Hanson RL, Craig DW, Millis MP, et al. Identification of doi: 10.1042/BSR20170036
PVT1 as a candidate gene for end-stage renal disease in
type 2 diabetes using a pooling-based genome-wide single 61. Gong Q, Dong W, Fan Y, et al. LncRNA TDRG1-mediated
nucleotide polymorphism association study. Diabetes. overexpression of VEGF aggravated retinal microvascular
2007;56(4):975-983. endothelial cell dysfunction in diabetic retinopathy. Front
Pharmacol. 2020;10:1703.
doi: 10.2337/db06-1072
doi: 10.3389/fphar.2019.01703
51. Zhou X, Liu S, Cai G, et al. Long non coding RNA MALAT1
promotes tumor growth and metastasis by inducing 62. Dong Y, Wan G, Peng G, Yan P, Qian C, Li F. Long non-
epithelial-mesenchymal transition in oral squamous cell coding RNA XIST regulates hyperglycemia-associated
carcinoma. Sci Rep. 2015;5(1):15972. apoptosis and migration in human retinal pigment epithelial
cells. Biomed Pharmacother. 2020;125:109959.
doi: 10.1038/srep15972
doi: 10.1016/j.biopha.2020.109959
52. Burzio VA, Villota C, Villegas J, et al. Expression of a family of
noncoding mitochondrial RNAs distinguishes normal from 63. Dai R, Sun Z, Qian Y, Zhang B, Han Y, Deng G. LncRNA
cancer cells. Proc Natl Acad Sci. 2009;106(23):9430-9434. LUADT1 inhibits cell apoptosis in diabetic retinopathy
by regulating miR-383/peroxiredoxin 3 axis. Arch Physiol
doi: 10.1073/pnas.0903086106 Biochem. 2022;128(3):637-642.
53. Young T, Matsuda T, Cepko C. The noncoding RNA taurine doi: 10.1080/13813455.2020.1716016
upregulated gene 1 is required for differentiation of the
murine retina. Curr Biol. 2005;15(6):501-512. 64. Bahtiyar G, Gutterman D, Lebovitz H. Heart failure: A major
cardiovascular complication of diabetes mellitus. Curr Diab
doi: 10.1016/j.cub.2005.02.027 Rep. 2016;16:116.
54. Uruno A, Furusawa Y, Yagishita Y, et al. The Keap1-Nrf2 doi: 10.1007/s11892-016-0809-4
system prevents onset of diabetes mellitus. Mol Cell Biol.
2013;33(15):2996-3010. 65. Aneja A, Tang WW, Bansilal S, Garcia MJ, Farkouh ME.
Diabetic cardiomyopathy: Insights into pathogenesis,
doi: 10.1128/MCB.00225-13 diagnostic challenges, and therapeutic options. Am J Med.
55. Wang L, Su N, Zhang Y, Wang G. Clinical significance of 2008;121(9):748-757.
serum lncRNA cancer susceptibility candidate 2 (CASC2) doi: 10.1016/j.amjmed.2008.03.046
for chronic renal failure in patients with type 2 diabetes. Med
Sci Monit. 2018;24:6079-6084. 66. Falcão-Pires I, Leite-Moreira AF. Diabetic cardiomyopathy:
Understanding the molecular and cellular basis to progress
doi: 10.12659/MSM.909510 in diagnosis and treatment. Heart Fail Rev. 2012;17:325-344.
56. Blackshaw S, Harpavat S, Trimarchi J, et al. Genomic analysis doi: 10.1007/s10741-011-9257-z
of mouse retinal development. PLoS Biol. 2004;2(9):E247.
67. Bugger H, Abel ED. Molecular mechanisms of diabetic
doi: 10.1371/journal.pbio.0020247 cardiomyopathy. Diabetologia. 2014;57:660-671.
57. Ohnishi Y, Tanaka T, Yamada R, et al. Identification of doi: 10.1007/s00125-014-3171-6

Volume 4 Issue 2 (2025) 13 doi: 10.36922/gpd.4000