Page 34 - GPD-4-2
P. 34
Gene & Protein in Disease lncRNAs dysregulation in diabetes and its complications
68. Gao Y, Wu F, Zhou J, et al. The H19/let-7 double-negative doi: 10.1111/jdi.13654
feedback loop contributes to glucose metabolism in muscle 79. Guay C, Kruit JK, Rome S, et al. Lymphocyte-derived
cells. Nucleic Acids Res. 2014;42(22):13799-13811.
exosomal microRNAs promote pancreatic β cell death and
doi: 10.1093/nar/gku1160 may contribute to type 1 diabetes development. Cell Metab.
2019;29(2):348-361.e6.
69. Zhuo C, Jiang R, Lin X, Shao M. LncRNA H19 inhibits
autophagy by epigenetically silencing of DIRAS in diabetic doi: 10.1016/j.cmet.2018.09.011
3
cardiomyopathy. Oncotarget. 2017;8(1):1429-1437.
80. Cao X, Xue LD, Di Y, Li T, Tian YJ, Song Y. MSC-derived
doi: 10.18632/oncotarget.13637 exosomal lncRNA SNHG7 suppresses endothelial-
mesenchymal transition and tube formation in diabetic
70. Keniry A, Oxley D, Monnier P, et al. The H19 lincRNA is a
developmental reservoir of miR-675 that suppresses growth retinopathy via miR-34a-5p/XBP1 axis. Life Sci.
and Igf1r. Nat Cell Biol. 2012;14(7):659-665. 2021;272:119232.
doi: 10.1016/j.lfs.2021.119232
doi: 10.1038/ncb2521
81. Zhang J, Chen K, Tang Y, et al. LncRNA-HOTAIR activates
71. Li X, Wang H, Yao B, Xu W, Chen J, Zhou X. lncRNA
H19/miR-675 axis regulates cardiomyocyte apoptosis autophagy and promotes the imatinib resistance of
by targeting VDAC1 in diabetic cardiomyopathy. Sci gastrointestinal stromal tumor cells through a mechanism
Rep. 2016;6(1):36340. involving the miR-130a/ATG2B pathway. Cell Death Dis.
2021;12(4):367.
doi: 10.1038/srep36340
doi: 10.1038/s41419-021-03650-7
72. Dey BK, Pfeifer K, Dutta A. The H19 long noncoding RNA
gives rise to microRNAs miR-675-3p and miR-675-5p to 82. Bhan A, Mandal SS. LncRNA HOTAIR: A master regulator
promote skeletal muscle differentiation and regeneration. of chromatin dynamics and cancer. Biochim Biophys Acta.
Genes Dev. 2014;28(5):491-501. 2015;1856(1):151-164.
doi: 10.1016/j.bbcan.2015.07.001
doi: 10.1101/gad.234419.113
83. Cantile M, Di Bonito M, Cerrone M, Collina F, De
73. Jiang X, Lei R, Ning Q. Circulating long noncoding RNAs
as novel biomarkers of human diseases. Biomark Med. Laurentiis M, Botti G. Long non-coding RNA HOTAIR in
2016;10(7):757-769. breast cancer therapy. Cancers (Basel). 2020;12(5):1197.
doi: 10.3390/cancers12051197
doi: 10.2217/bmm-2016-0039
84. Biswas S, Feng B, Chen S, et al. The long non-coding RNA
74. Yuan S, Xiang Y, Guo X, et al. Circulating long noncoding
RNAs act as diagnostic biomarkers in non-small cell lung HOTAIR is a critical epigenetic mediator of angiogenesis
cancer. Front Oncol. 2020;10:537120. in diabetic retinopathy. Invest Ophthalmol Vis Sci.
2021;62(3):20.
doi: 10.3389/fonc.2020.537120
doi: 10.1167/iovs.62.3.20
75. De Gonzalo-Calvo D, Kenneweg F, Bang C, et al. Circulating
long noncoding RNAs in personalized medicine: Response 85. Qi K, Zhong J. LncRNA HOTAIR improves diabetic
to pioglitazone therapy in type 2 diabetes. J Am Coll Cardiol. cardiomyopathy by increasing viability of cardiomyocytes
2016;68(25):2914-2916. through activation of the PI3K/Akt pathway. Exp Ther Med.
2018;16(6):4817-4823.
doi: 10.1016/j.jacc.2016.10.014
doi: 10.3892/etm.2018.6755
76. Conigliaro A, Costa V, Lo Dico A, et al. CD90+ liver cancer
cells modulate endothelial cell phenotype through the 86. Li M, Guo Y, Wang X, Duan B, Li L. HOTAIR participates in
release of exosomes containing H19 lncRNA. Mol Cancer. hepatic insulin resistance via regulating SIRT1. Eur Rev Med
2015;14(1):155. Pharmacol Sci. 2018;22(22):7883-7890.
doi: 10.26355/eurrev_201811_16414
doi: 10.1186/s12943-015-0426-x
87. Lodde V, Murgia G, Simula ER, Steri M, Floris M, Idda ML.
77. Jiao Z, Yu A, Rong W, et al. Five-lncRNA signature in
plasma exosomes serves as diagnostic biomarker for Long noncoding RNAs and circular RNAs in autoimmune
esophageal squamous cell carcinoma. Aging (Albany NY). diseases. Biomolecules. 2020;10(7):1044.
2020;12(14):15002-15010. doi: 10.3390/biom10071044
doi: 10.18632/aging.103559 88. Notarte KI, Senanayake S, Macaranas I, et al. MicroRNA and
other non-coding RNAs in Epstein-Barr virus-associated
78. Lee J, Lee SH. New mediators in diabetes pathogenesis:
Exosomes and metabolites. J Diabet Investig. cancers. Cancers (Basel). 2021;13(15):3909.
2021;12(11):1931-1933. doi: 10.3390/cancers13153909
Volume 4 Issue 2 (2025) 14 doi: 10.36922/gpd.4000

