Page 21 - GPD-4-3

Gene & Protein in Disease Targeting cathepsins during cancer development

32. Delbridge AR, Strasser A. The BCL-2 protein family, 43. Kleer CG, Bloushtain-Qimron N, Chen YH, et al. Epithelial
BH3-mimetics and cancer therapy. Cell Death Differ. and stromal cathepsin K and CXCL14 expression in breast
2015;22(7):1071-1080. tumor progression. Clin Cancer Res. 2008;14(17):5357-5367.
doi: 10.1038/cdd.2015.50 doi: 10.1158/1078-0432.CCR-08-0732
33. Merino D, Kelly GL, Lessene G, Wei AH, Roberts AW, 44. Gocheva V, Zeng W, Ke D, et al. Distinct roles for cysteine
Strasser A. BH3-mimetic drugs: Blazing the trail for new cathepsin genes in multistage tumorigenesis. Genes Dev.
cancer medicines. Cancer Cell. 2018;34(6):879-891. 2006;20(5):543-556.
doi: 10.1016/j.ccell.2018.11.004 doi: 10.1101/gad.1407406
34. Turk V, Stoka V, Vasiljeva O, et al. Cysteine cathepsins: From 45. Jedeszko C, Sloane BF. Cysteine cathepsins in human cancer.
structure, function and regulation to new frontiers. Biochim Biol Chem. 2004;385(11):1017-1027.
Biophys Acta. 2012;1824(1):68-88.
doi: 10.1515/BC.2004.132
doi: 10.1016/j.bbapap.2011.10.002
46. Ebert MP, Kruger S, Fogeron ML, et al. Overexpression
35. Pogorzelska A, Zolnowska B, Bartoszewski R. Cysteine of cathepsin B in gastric cancer identified by proteome
cathepsins as a prospective target for anticancer therapies- analysis. Proteomics. 2005;5(6):1693-1704.
current progress and prospects. Biochimie. 2018;51:85-106.
doi: 10.1002/pmic.200401030
doi: 10.1016/j.biochi.2018.05.023
47. Bengsch F, Buck A, Gunther SC, et al. Cell type-dependent
36. Kozlowski L, Rucinska M, Wojtukiewicz MZ. Metastases pathogenic functions of overexpressed human cathepsin
of malignant melanoma of unknown primary site: An B in murine breast cancer progression. Oncogene.
important diagnostic and therapeutic problem. Pol Merkur 2014;33(36):4474-4484.
Lekarski. 2000;8(49):486-488.
doi: 10.1038/onc.2013.395
37. Sloane BF, Dunn JR, Honn KV. Lysosomal cathepsin 48. Qin G, Cai Y, Long J, et al. Cathepsin L is involved in
B: Correlation with metastatic potential. Science.
1981;212(4499):1151-1153. proliferation and invasion of breast cancer cells. Neoplasma.
2016;63(1):30-36.
doi: 10.1126/science.7233209
doi: 10.4149/neo_2016_004
38. Dian D, Vrekoussis T, Shabani N, et al. Expression of 49. Wang W, Long L, Wang L, et al. Knockdown of Cathepsin L
cathepsin-D in primary breast cancer and corresponding
local recurrence or metastasis: An immunohistochemical promotes radiosensitivity of glioma stem cells both in vivo
study. Anticancer Res. 2012;32(3):901-905. and in vitro. Cancer Lett. 2016;71(2):274-284.
doi: 10.1016/j.canlet.2015.12.012
39. Fujise N, Nanashim A, Taniguchi Y, et al. Prognostic impact
of cathepsin B and matrix metalloproteinase-9 in pulmonary 50. Mehrotra S, Wickremesekera SK, Brasch HD, et al. Expression
adenocarcinomas by immunohistochemical study. Lung and localization of cathepsins B, D and G in cancer stem
Cancer. 2000;27(1):19-26. cells in liver metastasis from colon adenocarcinoma. Front
Surg. 2018;5:40.
doi: 10.1016/s0169-5002(99)00088-4
doi: 10.3389/fsurg.2018.00040
40. Pruitt FL, He Y, Franco OE, Jiang M, Cates JM, Hayward
SW. Cathepsin D acts as an essential mediator to promote 51. Featherston T, Marsh RW, van Schaijik B, Brasch HD, Tan ST,
malignancy of benign prostatic epithelium. Prostate. Itinteang T. Expression and localization of cathepsins B, D,
2013;73(5):476-488. and G in two cancer stem cell subpopulations in moderately
differentiated oral tongue squamous cell carcinoma. Front
doi: 10.1002/pros.22589
Med (Lausanne). 2017;4:100.
41. Krueger S, Kalinski T, Wolf H, Kellner U, Roessner A.
Interactions between human colon carcinoma cells, doi: 10.3389/fmed.2017.00100
fibroblasts and monocytic cells in coculture--regulation 52. Breznik B, Limbaeck Stokin C, Kos J, et al. Cysteine cathepsins
of cathepsin B expression and invasiveness. Cancer Lett. B, X and K expression in peri-arteriolar glioblastoma stem
2005;223(2):313-322. cell niches. J Mol Histol. 2018;9(5):481-497.
doi: 10.1016/j.canlet.2004.09.050 doi: 10.1007/s10735-018-9787-y
42. Sivaparvathi M, Sawaya R, Gokaslan ZL, Chintala SK, Rao JS. 53. Sui H, Shi C, Yan Z, Wu M. Overexpression of Cathepsin L
Expression and the role of cathepsin H in human glioma is associated with chemoresistance and invasion of epithelial
progression and invasion. Cancer Lett. 1996;104(1):121-126. ovarian cancer. Oncotarget. 2016;(29):45995-46001.
doi: 10.1016/0304-3835(96)04242-5 doi: 10.18632/oncotarget.10276

Volume 4 Issue 3 (2025) 10 doi: 10.36922/gpd.4768