Page 20 - GPD-4-3

Gene & Protein in Disease Targeting cathepsins during cancer development

10. Turk B, Turk D, Turk V. Lysosomal cysteine proteases: More than protease zymogen. J Mol Biol. 1997;271(5):774-788.
scavengers. Biochim Biophys Acta. 2000;1477(1-2):98-111.
doi: 10.1006/jmbi.1997.1218
doi: 10.1016/s0167-4838(99)00263-0
21. Renko M, Pozgan U, Majera D, Turk D. Stefin A displaces the
11. Soond SM, Zamyatnin AA Jr. Helicobacter pylori and gastric occluding loop of cathepsin B only by as much as required to
cancer: A lysosomal protease perspective. Gastric Cancer. bind to the active site cleft. FEBS J. 2010;277(20):4338-4345.
2022;25(2):306-324.
doi: 10.1111/j.1742-4658.2010.07824.x
doi: 10.1007/s10120-021-01272-8
22. Cory S, Adams JM. The Bcl2 family: Regulators of the cellular
12. Soond SM, Kozhevnikova MV, Savvateeva LV, Townsend PA, life-or-death switch. Nat Rev Cancer. 2002;2(9):647-656.
Zamyatnin AA Jr. Intrinsically connected: Therapeutically
targeting the cathepsin proteases and the Bcl-2 family of doi: 10.1038/nrc883
protein substrates as co-regulators of apoptosis. Int J Mol Sci. 23. Ola MS, Nawaz M, Ahsan H. Role of Bcl-2 family proteins
2021;22(9):4669. and caspases in the regulation of apoptosis. Mol Cell
Biochem. 2011;351(1-2):41-58.
doi: 10.3390/ijms22094669
13. De Castro MA, Bunt G, Wouters FS. Cathepsin B launches doi: 10.1007/s11010-010-0709-x
an apoptotic exit effort upon cell death-associated disruption 24. Garcia-Saez AJ. The secrets of the Bcl-2 family. Cell Death
of lysosomes. Cell Death Discov. 2016;2:16012. Differ. 2012;19(11):1733-1740.
doi: 10.1038/cddiscovery.2016.12 doi: 10.1038/cdd.2012.105
14. Turk B, Dolenc I, Turk V, Bieth JG, Kinetics of the 25. Youle RJ, Strasser A. The BCL-2 protein family: Opposing
pH-induced inactivation of human cathepsin L. activities that mediate cell death. Nat Rev Mol Cell Biol.
Biochemistry. 1993;32(1):375-380. 2008;9(1):47-59.
doi: 10.1021/bi00052a046 doi: 10.1038/nrm2308
15. Turk B, Bieth JG, Bjork I, et al. Regulation of the activity of 26. Huang DC, Adams JM, Cory S. The conserved N-terminal
lysosomal cysteine proteinases by pH-induced inactivation BH domain of Bcl-2 homologues is essential for inhibition
4
and/or endogenous protein inhibitors, cystatin. Biol Chem of apoptosis and interaction with CED-4. EMBO J.
Hoppe Seyler. 1995;376(4):225-230. 1998;17(4):1029-1039.
doi: 10.1515/bchm3.1995.376.4.225 doi: 10.1093/emboj/17.4.1029
16. Edgington LE, Verdoes M, Bogyo M. Functional imaging of 27. Kvansakul M, Yang H, Fairlie WD, et al. Vaccinia virus anti-
proteases: Recent advances in the design and application of apoptotic F1L is a novel Bcl-2-like domain-swapped dimer
substrate-based and activity-based probes. Curr Opin Chem that binds a highly selective subset of BH3-containing death
Biol. 2011;15(6):798-805. ligands. Cell Death Differ. 2008;15(10):1564-1571.
doi: 10.1016/j.cbpa.2011.10.012 doi: 10.1038/cdd.2008.83
17. Jain M, Bouilloux J, Borrego I, et al. Cathepsin B-cleavable 28. Townsend PA, Kozhevnikova MV, Cexus ONF,
polymeric photosensitizer prodrug for selective Zamyatnin AA Jr., Soond SM. BH3-mimetics: Recent
photodynamic therapy: In vitro studies. Pharmaceuticals developments in cancer therapy. J Exp Clin Cancer Res.
(Basel). 2022;15(5):564. 2021;40(1):355.
doi: 10.3390/ph15050564
doi: 10.1186/s13046-021-02157-5
18. Chowdhury MA, Moya IA, Bhilocha S, et al. Prodrug- 29. Lomonosova E, Chinnadurai G. BH3-only proteins
inspired probes selective to cathepsin B over other cysteine in apoptosis and beyond: An overview. Oncogene.
cathepsins. J Med Chem. 2014;57(14):6092-6104.
2008;27(Suppl 1):S2-S19.
doi: 10.1021/jm500544p
doi: 10.1038/onc.2009.39
19. Soond SM, Kozhevnikova MV, Townsend PA, 30. Flores-Romero H, Ros U, Garcia-Saez AJ. Pore formation in
Zamyatnin AA Jr. Cysteine cathepsin protease inhibition: regulated cell death. EMBO J. 2020;39(23):e105753.
An update on its diagnostic, prognostic and therapeutic
potential in cancer. Pharmaceuticals (Basel). 2019;12(2):87. doi: 10.15252/embj.2020105753
doi: 10.3390/ph12020087 31. Li P, Nijhawan D, Budihardjo I, et al. Cytochrome c and dATP-
dependent formation of Apaf-1/caspase-9 complex initiates
20. Podobnik M, Kuhelj R, Turk V, Turk D. Crystal structure
of the wild-type human procathepsin B at 2.5 A resolution an apoptotic protease cascade. Cell. 1997;91(4):479-489.
reveals the native active site of a papain-like cysteine doi: 10.1016/s0092-8674(00)80434-1

Volume 4 Issue 3 (2025) 9 doi: 10.36922/gpd.4768