Page 23 - GPD-4-3

Gene & Protein in Disease Targeting cathepsins during cancer development

1999;18(10):2692-2701. 86. Soond SM, Savvateeva LV, Makarov VA, Gorokhovets NV,
Townsend PA, Zamyatnin AA Jr. Cathepsin S cleaves BAX as
doi: 10.1093/emboj/18.10.2692
a novel and therapeutically important regulatory mechanism
76. Knudson CM, Tung KS, Tourtellotte WG, Brown GA, for apoptosis. Pharmaceutics. 2021;13(3):339.
Korsmeyer SJ. Bax-deficient mice with lymphoid hyperplasia doi: 10.3390/pharmaceutics13030339
and male germ cell death. Science. 1995;270(5233):96-99.
87. Bruncko M, Oost TK, Belli BA, et al. Studies leading to
doi: 10.1126/science.270.5233.96
potent, dual inhibitors of Bcl-2 and Bcl-xL. J Med Chem.
77. Lindsten T, Ross AJ, King A, et al. The combined functions 2007;50(4):641-662.
of proapoptotic Bcl-2 family members bak and bax are doi: 10.1021/jm061152t
essential for normal development of multiple tissues. Mol
Cell. 2000;6(6):1389-1399. 88. Oltersdorf T, Elmore SW, Shoemaker AR, et al. An inhibitor
of Bcl-2 family proteins induces regression of solid tumours.
doi: 10.1016/s1097-2765(00)00136-2 Nature. 2005;435(7042):677-681.
78. Fannjiang Y, Kim CH, Huganir RL, et al. BAK alters neuronal doi: 10.1038/nature03579
excitability and can switch from anti-to pro-death function
during postnatal development. Dev Cell. 2003;4(4):575-585. 89. Delbridge AR, Grabow S, Strasser A, Vaux DL. Thirty years
of BCL-2: Translating cell death discoveries into novel
doi: 10.1016/s1534-5807(03)00091-1 cancer therapies. Nat Rev Cancer. 2016;16(2):99-109.
79. Wei MC, Zong WX, Cheng EH, et al. Proapoptotic BAX and doi: 10.1038/nrc.2015.17
BAK: A requisite gateway to mitochondrial dysfunction and
death. Science. 2001;292(5517):727-730. 90. Gaussian N, Frontczak A, El Kaddissi A, et al. Systemic
treatment of locally advanced or metastatic penile cancer.
doi: 10.1126/science.1059108 Bull Cancer. 2020;107(5S):S17-S23.
80. Jaaskelainen M, Nieminen A, Pokkyla RM, et al. Regulation doi: 10.1016/S0007-4551(20)30274-5
of cell death in human fetal and adult ovaries--role of Bok
and Bcl-X(L). Mol Cell Endocrinol. 2010;330(1-2):17-24. 91. Kaiser U, Schilli M, Haag U, et al. Expression of bcl-2--protein
in small cell lung cancer. Lung Cancer. 1996;15(1):31-40.
doi: 10.1016/j.mce.2010.07.020
doi: 10.1016/0169-5002(96)00568-5
81. Ke F, Voss A, Kerr JB, et al. BCL-2 family member BOK is
widely expressed but its loss has only minimal impact in 92. Beroukhim R, Mermel CH, Porter D, et al. The landscape
of somatic copy-number alteration across human cancers.
mice. Cell Death Differ. 2012;19(6):915-925.
Nature. 2010;463(7283):899-905.
doi: 10.1038/cdd.2011.210 doi: 10.1038/nature08822
82. Suominen JS, Yan W, Toppari J, Kaipia A. The expression 93. Leverson JD, Phillips DC, Mitten MJ, et al. Exploiting
and regulation of Bcl-2-related ovarian killer (Bok) mRNA selective BCL-2 family inhibitors to dissect cell survival
in the developing and adult rat testis. Eur J Endocrinol. dependencies and define improved strategies for cancer
2001;145(6):771-778. therapy. Sci Transl Med. 2015;7(279):279ra40.
doi: 10.1530/eje.0.1450771 doi: 10.1126/scitranslmed.aaa4642
83. Cao X, Deng X, May WS. Cleavage of Bax to p18 Bax 94. Punnoose EA, Leverson JD, Peale F, et al. Expression profile
accelerates stress-induced apoptosis, and a cathepsin- of BCL-2, BCL-XL, and MCL-1 predicts pharmacological
like protease may rapidly degrade p18 Bax. Blood. response to the BCL-2 selective antagonist venetoclax
2003;102(7):2605-2614. in multiple myeloma models. Mol Cancer Ther.
doi: 10.1182/blood-2003-01-0211 2016;15(5):1132-1144.
84. Jurgensmeier JM, Xie Z, Deveraux Q, Ellerby L, Bredesen D, doi: 10.1158/1535-7163.MCT-15-0730
Reed JC. Bax directly induces release of cytochrome c 95. Motoyama N, Wang F, Roth KA, et al. Massive cell death
from isolated mitochondria. Proc Natl Acad Sci U S A. of immature hematopoietic cells and neurons in Bcl-x-
1998;95(9):4997-5002. deficient mice. Science. 1995;267(5203):1506-1510.
doi: 10.1073/pnas.95.9.4997 doi: 10.1126/science.7878471
85. Droga-Mazovec G, Bojic L, Petelin A, et al. Cysteine 96. Veis DJ, Sorenson CM, Shutter JR, Korsmeyer SJ. Bcl-2-
cathepsins trigger caspase-dependent cell death through deficient mice demonstrate fulminant lymphoid apoptosis,
cleavage of bid and antiapoptotic Bcl-2 homologs. J Biol polycystic kidneys, and hypopigmented hair. Cell.
Chem. 2008;283(27):19140-19150. 1993;75(2):229-240.
doi: 10.1074/jbc.M802513200 doi: 10.1016/0092-8674(93)80065-m

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