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Gene & Protein in Disease                                      Targeting cathepsins during cancer development



               doi: 10.3109/10428194.2015.1030638              129. Lee EF, Czabotar PE, van Delft MF, et al. A novel BH3 ligand
                                                                  that selectively targets Mcl-1 reveals that apoptosis can proceed
            118. Debrincat MA, Pleines I, Lebois M, et al. BCL-2 is
               dispensable for  thrombopoiesis  and  platelet  survival.  Cell   without Mcl-1 degradation. J Cell Biol. 2008;180(2):341-355.
               Death Dis. 2015;6(4):e1721.                        doi: 10.1083/jcb.200708096
               doi: 10.1038/cddis.2015.97                      130. Lee EF, Czabotar PE, Yang H, et al. Conformational changes
                                                                  in Bcl-2 pro-survival proteins determine their capacity to
            119. Mason KD, Carpinelli MR, Fletcher JI, et al. Programmed   bind ligands. J Biol Chem. 2009;284(44):30508-30517.
               anuclear  cell  death  delimits  platelet  life  span.  Cell.
               2007;128(6):1173-1186.                             doi: 10.1074/jbc.M109.040725
               doi: 10.1016/j.cell.2007.01.037                 131. Nakao S, Zandi S, Sun D,Hafezi-Moghadam A. Cathepsin
                                                                  B-mediated CD18 shedding regulates leukocyte recruitment
            120. Roberts AW, Davids MS, Pagel JM, et al. Targeting BCL2   from angiogenic vessels. FASEB J. 2018;32(1):143-154.
               with venetoclax in relapsed chronic lymphocytic leukemia.
               N Engl J Med. 2016;374(4):311-322.                 doi: 10.1096/fj.201601229R
               doi: 10.1056/NEJMoa1513257                      132. Oskarsson T. Extracellular matrix components in breast cancer
                                                                  progression and metastasis. Breast. 2013;22(Suppl 2):S66-S72.
            121. Souers AJ, Leverson JD, Boghaert ER, et al. ABT-199, a potent
               and selective BCL-2 inhibitor, achieves antitumor activity      doi: 10.1016/j.breast.2013.07.012
               while sparing platelets. Nat Med. 2013;19(2):202-208.  133. Wang B, Sun J, Kitamoto S, et al. Cathepsin S controls
               doi: 10.1038/nm.3048                               angiogenesis and tumor growth via matrix-derived
                                                                  angiogenic factors. J Biol Chem. 2006;281(9):6020-6029.
            122. Stilgenbauer S, Eichhorst B, Schetelig J, et al. Venetoclax
               in relapsed or refractory chronic lymphocytic leukaemia      doi: 10.1074/jbc.M509134200
               with 17p deletion: A multicentre, open-label, phase 2 study.   134. Guinec N, Dalet-Fumeron V, Pagano M. “In  vitro” study
               Lancet Oncol. 2016;17(6):768-778.                  of  basement  membrane  degradation  by  the  cysteine
               doi: 10.1016/S1470-2045(16)30019-5                 proteinases, cathepsins B, B-like and L. Digestion of collagen
                                                                  IV, laminin, fibronectin, and release of gelatinase activities
            123. Tahir SK, Smith ML, Hessler P, et al. Potential mechanisms   from basement membrane fibronectin.  Biol  Chem  Hoppe
               of resistance to venetoclax and strategies to circumvent it.   Seyler. 1993;374(12):1135-1146.
               BMC Cancer. 2017;17(1):399.
                                                                  doi: 10.1515/bchm3.1993.374.7-12.1135
               doi: 10.1186/s12885-017-3383-5
                                                               135. Mai J, Sameni M, Mikkelsen T, Sloane BF. Degradation of
            124. Koehler MF, Bergeron P, Choo EF, et al. Structure-guided   extracellular matrix protein tenascin-C by cathepsin B: An
               rescaffolding of selective antagonists of BCL-XL. ACS Med   interaction  involved  in  the  progression  of  gliomas.  Biol
               Chem Lett. 2014;5(6):662-667.                      Chem. 2002;383(9):1407-1413.
               doi: 10.1021/ml500030p                             doi: 10.1515/BC.2002.159

            125. Lessene G, Czabotar PE, Sleebs BE, et al. Structure-guided   136. Felbor U, Dreier L, Bryant RA, Ploegh HL, Olsen BR,
               design of a selective BCL-X(L) inhibitor.  Nat  Chem  Biol.   Mothes W. Secreted cathepsin L generates endostatin from
               2013;9(6):390-397.                                 collagen XVIII. EMBO J. 2000;19(6):1187-1194.
               doi: 10.1038/nchembio.1246                         doi: 10.1093/emboj/19.6.1187
            126. Tao ZF, Hasvold L, Wang L, et al. Discovery of a potent and   137. Veillard F, Saidi A, Burden RE et al. Cysteine cathepsins S
               selective BCL-XL inhibitor with in vivo activity. ACS Med   and L  modulate anti-angiogenic  activities  of  human
               Chem Lett. 2014;5(10):1088-1093.                   endostatin. J Biol Chem. 2011;286(43):37158-37167.
               doi: 10.1021/ml5001867                             doi: 10.1074/jbc.M111.284869
            127. Wei G, Margolin AA, Haery L, et al. Chemical genomics   138. Gineyts E, Bonnet N, Bertholon C, et al. The C-terminal
               identifies small-molecule MCL1 repressors and Bcl-xL as   intact forms of periostin (iPTN) are surrogate markers
               a predictor of MCL1 dependency. Cancer Cell. 2012;21(4):   for osteolytic lesions in experimental breast cancer bone
               547-562.                                           metastasis. Calcif Tissue Int. 2018;103(5):567-580.
               doi: 10.1016/j.ccr.2012.02.028                     doi: 10.1007/s00223-018-0444-y
            128. Wertz IE, Kusam S, Lam C, et al. Sensitivity to antitubulin   139. Podgorski I, Linebaugh BE, Koblinski JE, et al. Bone marrow-
               chemotherapeutics is regulated by MCL1 and FBW7.   derived cathepsin K cleaves SPARC in bone metastasis. Am
               Nature. 2011;471(7336):110-114.                    J Pathol. 2009;175(3):1255-1269.
               doi: 10.1038/nature09779                           doi: 10.2353/ajpath.2009.080906


            Volume 4 Issue 3 (2025)                         14                              doi: 10.36922/gpd.4768
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