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Gene & Protein in Disease TNFA polymorphism and risk of endometriosis

HWE (FDR) 0.78 0.78 0.78 NA 0.78 0.78 0.97 0.97 *0.0008 0.97 NA NA 1 0.97 0.91 0.97 *<0.05 *<0.05 0.63 0.63 NA NA 0.63 0.63 0.22 0.46 NA NA 0.22 *0.002 0.46 (Cont’d...)
Table 3. Characteristics of studies eligible for meta‑analysis of tumor necrosis factor‑alpha variants( ‑238 G>A, ‑308 G>A, ‑850 C>T, ‑857 C>T, ‑863 C>A, and ‑1031
HW 62 178 168 27 135 49 180 80 174 65 84 127 171 2 60 120 112 173 102 127 121 166 13 99
Control HT 7 24 7 31 14 18 22 18 5 0 21 21 15 77 2 55 46 67 36 45 42 78 46 44

HR 0 0 0 7 0 2 0 8 0 0 2 2 0 6 3 8 7 8 5 8 2 4 6 7

HW 84 56 127 36 137 73 60 86 125 65 160 131 159 4 63 83 89 172 102 90 98 148 7 114

Case HT 8 14 1 22 11 15 10 25 1 0 64 18 24 79 0 43 32 67 43 30 23 92 51 32

HR 0 0 1 No data given 7 2 4 0 9 0 No data given No data given 0 27 1 0 27 2 4 2 No data given No data given 7 3 9 2 No data given No data given 6 7 4

Genotyping tech PCR-RFLP Multiplex PCR-RFLP SNP-Array PCR-RFLP PCR-RFLP PCR-RFLP Multiplex PCR-RFLP PCR-RFLP SNP-array Sequencing PCR-RFLP PCR-RFLP PCR-RFLP PCR-RFLP PCR-RFLP PCR-RFLP PCR-RFLP PCR-PHFA SNP-array PCR-RFLP PCR-RFLP PCR-RFLP PCR-RFLP PCR-PHFA PCR-RFLP SNP-array PCR-RFLP PCR-RFLP PCR-RFLP

Case/ Control 92/69 70/202 129/175 958/959 65/65 150/149 92/69 70/202 120/106 129/175 958/959 24/18 65/65 251/107 150/149 183/186 110/50 65/65 129/175 123/165 958/959 210/202 246/248 150/149 129/175 123/165 210/202 958/959 246/248 65/65 150/149

Source of control HB NG PB HB HB HB HB NG HB PB HB HB HB HB HB HB HB HB PB HB HB HB HB HB PB HB HB HB HB HB HB

Type of study CC CC CC CH CC CC CC CC CC CC CH CC CC CC CC CC CC CC CC CC CH CC CC CC CC CC CC CH CC CC CC

Ethnicity Caucasian Asian Asian Caucasian Asian Asian Caucasian Asian Asian Asian Caucasian Caucasian Asian Caucasian Asian Caucasian Asian Asian Asian Asian Caucasian Asian Asian Asian Asian Asian Asian Caucasian Asian Asian Asian

T>C0 and their association with the risk of endometriosis
Country Australia South Korea Japan Australia Iran Iran Australia South Korea Taiwan Japan Australia USA Iran Russia Iran Mexico India Iran Japan Japan Australia Korea South Korea Iran Japan Japan Korea Australia South Korea Iran Iran

YOP 2002 2002 2004 2007 2015 2019 2002 2002 2002 2004 2007 2012 2015 2018 2019 2022 2010 2014 2004 2004 2007 2008 2008 2019 2004 2004 2008 2007 2008 2014 2019

Authors Wieser et al. 17 Lee et al. 11 Asghar et al. 21 Zhao et al. 12 Abutorabi et al. 26 Babaabasi et al. 27 Wieser et al. 17 Lee et al. 11 Hsieh et al. 13 Asghar et al. 21 Zhao et al. 12 Rotman et al. 14 Abutorabi et al. 26 Kublinsky et al. 16 Babaabasi et al. 27 Mier-Cabrera et al. 28 Lakshhmi et al. 31 Mardanian et al. 29 Asghar et al. 21 Teramoto et al. 30 Zhao et al. 12 Chae et al. 18 Lee et al. 15

No. 1 2 3 4 5 6 1 2 3 4 5 6 7 8 9 10 1 2 1 2 3 4 5 6 1 2 3 4 5 6 7

Variant -238 G>A -308 G>A -850 C>T -857 C>T -863 C>A

Volume 4 Issue 3 (2025) 4 doi: 10.36922/gpd.5204