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Gene & Protein in Disease TNFA polymorphism and risk of endometriosis

Figure 2. Systematic workflow of the included studies according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses

between this variant and disease risk in different The results indicated that patients had a slightly higher
populations (Table 3). However, Zhao et al. did not frequency of the risk allele (AA = 1.97%) compared to
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provide genotypic data in their published article, leading controls (AA = 1.06%) in terms of genotypic frequency
to their exclusion from the final analysis. The remaining (AA). After determining the gene frequency, we examined
studies included 1,166 subjects, comprising 506 cases the risk association across several genetic models. For
and 660 healthy controls. Upon examining the studies for instance, the allele model showed an OR of 0.97 (95% CI:
HWE, we found that all studies adhered to HWE principles 0.69 – 1.35) (Figure 3A), the recessive model yielded an
(Table 3). OR of 1.36 (95% CI: 0.50 – 3.65), the dominant model

Volume 4 Issue 3 (2025) 6 doi: 10.36922/gpd.5204