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Global Translational Medicine Inflammatory gene-environment interactions in COPD

Education and Science of Russian Federation (No. References
AAAA-A21-121011990119-1) and Megagrant from the 1. Barnes PJ, 2016, Inflammatory mechanisms in patients
Government of Russian Federation (2020-220-08-2197).
with chronic obstructive pulmonary disease. J Allergy Clin
Conflict of interest Immunol, 138(1): 16–27.
https://doi.org/10.1016/j.jaci.2016.05.011
None of the authors have conflicts of interest to report with
regard to this manuscript. 2. Decramer M, Janssens W, Miravitlles M, 2012, Chronic
obstructive pulmonary disease. Lancet, 379: 1341–1351.
Author contributions https://doi.org/10.1016/S0140-6736(11)60968-9

Conceptualization: Gulnaz F. Korytina 3. Song Q, Chen P, Liu XM, 2021, The role of cigarette smoke-
Formal analysis: Timur R. Nasibullin induced pulmonary vascular endothelial cell apoptosis in
Funding acquisition: Gulnaz F. Korytina COPD. Respir Res, 22(1): 39.
Investigation: Yulia G. Aznabaeva, Olga V. Kochetova, https://doi.org/10.1186/s12931-021-01630-1
Natalia N. Khusnutdinova
Methodology: Gulnaz F. Korytina, Yulia G. Aznabaeva, 4. Hurst JR, Siddiqui MK, Singh B, et al., 2021, A systematic
Naufal Sh. Zagidullin literature review of the humanistic burden of COPD. Int J
Project administration: Gulnaz F. Korytina Chron Obstruct Pulmon Dis, 16: 1303–1314.
Resources: Yulia G. Aznabaeva, Naufal Sh. Zagidullin https://doi.org/10.2147/COPD.S296696
Supervision: Naufal Sh. Zagidullin 5. An L, Lin Y, Yang T, et al., 2016, Exploring the interaction
Validation: Olga V. Kochetova, Natalia N. Khusnutdinova, among EPHX1, GSTP1, SERPINE2, and TGFB1 contributing
Tatyana V. Viktorova to the quantitative traits of chronic obstructive pulmonary
Visualization: Timur R. Nasibullin disease in Chinese Han population. Hum Genomics, 10(1): 13.
Writing – original draft: Gulnaz F. Korytina https://doi.org/10.1186/s40246-016-0076-0
Writing – review and editing: Gulnaz F. Korytina, Tatyana
V. Viktorova 6. Kirkham PA, Barnes PJ. 2013, Oxidative stress in COPD.
Chest, 144(1): 266–273.
All authors critically commented and approved the
manuscript. https://doi.org/10.1378/chest.12-2664
7. Silverman EK, 2020, Genetics of COPD. Annu Rev Physiol,
Ethics approval and consent to participate 82: 413–431.

The study was approved by the Ethics Committee of https://doi.org/10.1146/annurev-physiol-021317-121224
Institute of Biochemistry and Genetics of Ufa Scientific 8. Ahmadi A, Ghaedi H, Salimian J, et al., 2019, Association
Center of Russian Academy of Sciences (IBG USC RAS), between chronic obstructive pulmonary disease and
Ufa, Russia (Ufa, Protocol No 17, December 7, 2010). interleukins gene variants: A systematic review and meta-
All procedures carried out in the study involving the analysis. Cytokine, 117: 65–71.
participation of people are in compliance with the Ethical https://doi.org/10.1016/j.cyto.2019.02.003
Standards of the Institutional and/or National Research 9. Caramori G, Adcock IM, Di Stefano A, 2014, Cytokine
Ethics Committee and the 1964 Helsinki Declaration and inhibition in the treatment of COPD. Int J Chron Obstruct
its subsequent changes or comparable standards of ethics. Pulmon Dis, 9: 397–412.
Informed voluntary consent was obtained from each of the
participants in the study. https://doi.org/10.2147/COPD.S42544
10. Ponce-Gallegos MA, Pérez-Rubio G, Ambrocio-Ortiz E,
Consent for publication et al., 2020, Genetic variants in IL17A and serum levels
of IL-17A are associated with COPD related to tobacco
Written informed consent for the publication of any smoking and biomass burning. Sci Rep, 10(1): 784.
associated data was obtained from each of the participants
in the study. https://doi.org/10.1038/s41598-020-57606-6
11. Hackett TL, Holloway R, Holgate ST, et al., 2008, Dynamics
Availability of data and material of pro-inflammatory and anti-inflammatory cytokine
The datasets generated during and/or analyzed during the release during acute inflammation in chronic obstructive
current study are available from the corresponding author pulmonary disease: An ex vivo study. Respir Res, 9(1): 47.
on reasonable request. https://doi.org/10.1186 / 1465-9921-9-47

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