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Global Translational Medicine Inflammatory gene-environment interactions in COPD

Table 7. Association of inflammatory gene loci with lung function parameters and smoking index
Gene, SNP Model Mean±S.E. P‑value b (95% CI)
FVC
FAS, rs1800682 A>G AA 50.97 (1.59) 0.041 0.00
AG + GG 55.59 (1.44) 4.62 (0.20 – 9.03)
Dominant
IL4, rs2243250 C>T CC + CT 56.34 (1.27) 0.017 0.00-10.01 (−18.18 – −1.89)
TT 46.33 (3.04)
Recessive
IL4RA, rs1805010 A>G AA 51.29 (1.78) 0.031 0.00
AG + GG 56.15 (1.35) 4.87 (0.45 – 9.28)
Dominant
AA + GG 52.00 (1.34) 0.009 0.00
AG 57.66 (1.73) 5.66 (1.43 – 9.90)
PPBP, rs352010 T>C CC 55.15 (1.3) 0.011 0.00−5.79 (−10.23 – −1.35)
CT + TT 49.36 (1.72)
Dominant
FASLG, rs763110 C>T CC + CT 54.56 (1.19) 0.049 0.00−5.77 (−11.49 – −0.05)
TT 48.79 (2.35)
Recessive
CC + TT 51.73 (1.29) 0.025 0.00
CT 56.65 (1.85) 4.92 (0.63 – 9.20)
FEV1
IL4RA, rs1805010 A>G AA + GG 38.67 (1.07) 0.024 0.00
AG 42.37 (1.25) 3.70 (0.49 – 6.92)
FASLG, rs763110 C>T CC + TT 38.46 (0.99) 0.038 0.00
CT 41.89 (1.36) 3.43 (0.19 – 6.67)
Smoking index in pack-years
IL19, rs2243193 A>G GG 33.52 (1.27) 0.04 0.00−3.54 (−6.91 – −0.17)
GA + AA 29.98 (1.12)
Dominant
IL4, rs2070874 C>T CC + CT 31.72 (0.84) 0.0075 0.00−13.01 (−22.53 – −3.49)
TT 18.7 (2.39)
Recessive
TGFb1, rs1800469 T>C CC 32.89 (1.31) 0.042 0.00−3.46 (−9.67 – −0.51)
CT + TT 29.43 (1.1)
Dominant
PPBP, rs352010 T>C CC 32.49 (1) 0.029 0.00−3.77 (−7.15 – −0.40)
CT + TT 28.72 (1.36)
Dominant
CC + CT 32.67 (0.95) 0.0021 0.00−5.76 (−9.43 – −2.09)
TT 26.91 (1.52)
Recessive
FASLG, rs763110 C>T CC 32.97 (1.31) 0.049 0.00−3.25 (−6.48 – −0.02)
CT + TT 29.72 (1.04)
Dominant
b, beta coefficient; mean±S.E., mean and standard error; P, two-sided P values for linear regression analysis adjusting for covariates (age, gender, BMI,
and smoking status for lung function parameters). FEV1, forced expiratory volume in 1 second; FVC, forced vital capacity.

patterns associated with increased risk of COPD in non- We established the association of PPBP (rs352010)
smokers. While the C allele of IL24 (rs291107) was observed with COPD both in smokers and non-smokers. At
in protective patterns. The study by Vargas-Alarcón et al. the same time, the significance of the association in
revealed the association of IL24 functional SNPs with smokers was higher. TT genotype of PPBP (rs352010)
cardiovascular disease in the Mexican population . was associated with increased risk of COPD and
[37]

Volume 1 Issue 1 (2022) 9 https://doi.org/10.36922/gtm.v1i1.91