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Global Translational Medicine                                 Bioinformatics analysis of dilated cardiomyopathy



            researchers will continue to explore the mechanisms of      https://doi.org/10.1161/CIR.0000000000000455
            DCM at the genetic level.                          4.   Mahmaljy  H,  Yelamanchili  VS,  Singhal  M,  2021,  Dilated
                                                                  Cardiomyopathy. StatPearls, Treasure Island, FL.
            5. Conclusion
                                                               5.   Dec GW, Fuster V, 1994, Idiopathic dilated cardiomyopathy.
            Our study found that five genes (ASPN,  OGN,  MME,    N Engl J Med, 331: 1564–1575.
            NPPA, and SFRP4) are potential hub genes. The associated   6.   Merlo M, Cannatà A, Gobbo M,  et al., 2018, Evolving
            mRNA-miRNA-lncRNA network was also established in     concepts in dilated cardiomyopathy.  Eur J Heart Fail,
            the study. Our findings may also provide clues for exploring   20: 228–239.
            the mechanisms, diagnostic biomarkers and genetic-level
            treatments of DCM with heart failure.                 https://doi.org/10.1002/ejhf.1103
                                                               7.   Cao Z, Jia Y, Zhu B, 2019, BNP and NT-proBNP as diagnostic
            Acknowledgments                                       biomarkers for cardiac dysfunction in both clinical and
                                                                  forensic medicine. Int J Mol Sci, 20: 1820.
             None.
                                                                  https://doi.org/10.3390/ijms20081820
            Funding                                            8.   Lakdawala NK, Winterfield JR, Funke BH, 2013, Dilated
            This work was supported by the National Natural Science   cardiomyopathy. Circ Arrhythm Electrophysiol, 6: 228–237.
            Foundation of China (U2005202) and the Fujian Province      https://doi.org/10.1161/CIRCEP.111.962050
            Major Science and Technology Program (2018YZ001-1).  9.   Akalin PK, 2006, Introduction to bioinformatics. Mol Nutr

            Conflict of interest                                  Food Res, 50: 610–619.
                                                                  https://doi.org/10.1002/mnfr.200500273
            The authors declare that the research was conducted in the
            absence of any commercial or financial relationships that   10.  Manfredi  M,  Brandi  J,  Di  Carlo  C,  et  al.,  2019,  Mining
            could be construed as a potential conflict of interest.  cancer biology through bioinformatic analysis of proteomic
                                                                  data. Expert Rev Proteom, 16: 733–747.
            Author contribution                                   https://doi.org/10.1080/14789450.2019.1654862

            Conceptualization: Xiaojie Yang, Tianci Chai, Liangwan   11.  Edgar R, Domrachev M, Lash AE, 2002, Gene expression
               Chen                                               omnibus: NCBI gene expression and hybridization array
            Data curation: Liming Li, Meiling Cai, Zhihuang Qiu   data repository. Nucleic Acids Res, 30: 207–210.
            Formal analysis: Xinghui Zhuang, Mengyue Tian         https://doi.org/10.1093/nar/30.1.207
            Methodology:  Xinghui  Zhuang,  Mengyue  Tian,  Shurong   12.  Cowen L, Ideker T, Raphael BJ,  et al., 2017, Network
               Xu                                                 propagation:  a  universal  amplifier  of genetic associations.
            Writing – original draft: Xinghui Zhuang, Mengyue Tian  Nat Rev Genet, 18: 551–562.
            Writing – review and editing: Xiaojie Yang, Tianci Chai     https://doi.org/10.1038/nrg.2017.38
            All authors have read and approved the original manuscript.
                                                               13.  Salmena  L,  Poliseno L,  Tay  Y,  et  al.,  2011,  A  ceRNA
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            Volume 1 Issue 1 (2022)                         13                     https://doi.org/10.36922/gtm.v1i1.104
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