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Global Translational Medicine Bioinformatics analysis of dilated cardiomyopathy

Figure 9. The mRNA-miRNA-lncRNA network associated with ASPN, MME, and SFRP4.
and the methylation of NPPA promoter may be associated the mRNA-miRNA-lncRNA network and may be a gene
with hypertension [36,37] . Our results showed that NPPA was therapy target for DCM.
involved in cardiomyocyte growth, differentiation, and The background and hypothesis postulated in the above
hypertrophy. In particular, NPPA was involved in mast cell may be helpful for researchers in exploring the pathogenic
activation, degranulation, and mast cell-mediated immune mechanism of DCM. By knocking out these highly
responses. We speculate that mast cells may lead to DCM expressed genes in DCM models, researchers may observe
by increasing the secretion of ANP. the disease development, which might be insightful for the
Low expression of SFRP4 inhibits apoptosis and development of disease treatment. According to the ROC
attenuates post-ischemic cardiomyocytes injury of mice . curves, these five hub genes are better at diagnosing DCM,
[38]
Our results revealed that SFRP4 was engaged in the and when combined together for diagnosing DCM, they
regulation of serine/threonine kinase signaling pathway, showed the best diagnostic efficacy. Therefore, genetic
Wnt signaling pathway, BMP signaling pathway, and tests can be performed on patients to detect the expression
growth factor stimulation responses. These pathways and levels of these genes, which could be used to guide
responses may be linked to the pathogenic mechanisms of the differential diagnosis of DCM from NF condition,
DCM. although conventional diagnostic indicators should still be
Hsa-miR-26b-5p has been reported to have employed.
antifibrotic effects in mouse cardiac fibroblasts . Its low In conclusion, DCM is a type of myocardial disease
[39]
expression promotes the procession of hypertrophy in rat that seriously threatens human health, and more in-depth
[40]
cardiomyocytes through exercising . In this study, hsa- studies concerning the causes and mechanisms of DCM
miR-26b-5p interacted with ASPN, MME, and SFRP4 in are required. Next-generation gene sequencing can identify

Volume 1 Issue 1 (2022) 11 https://doi.org/10.36922/gtm.v1i1.104