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Global Translational Medicine ctDNA in management of patients with NSCLC
Figure 1. Origin of ctDNA and research progresses in lung cancer. ctDNA is a kind of fragmented DNA pieces in the bloodstream shed by tumor cells
undergoing apoptosis or necrosis or through secretion. ctDNA has utility in the whole treatment process of lung cancer. In the early detection of cancer,
ctDNA can be used as a sensitive tool to decide a suspicious nodule on CT. In postoperative MRD detection, ctDNA after surgery reflects the fluctuation
of tumor burden and acts as an early warning of relapse before traditional detection. According to tumor-informed panel, ctDNA can be used to monitor
intratumor subclonal evolution. ctDNA detection can also be used to monitor therapeutic effect and discern patients with high risk of relapse, which
provides a clue as to whether escalate adjuvant therapy in order to prevent further development.
Volume 1 Issue 1 (2022) 2 https://doi.org/10.36922/gtm.v1i1.96
