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Global Translational Medicine Succinate metabolism in CVD

evidence reveals that succinate metabolism has a significant cardiomyopathy. Cardiovasc Res, 113: 389–398.
role in the pathophysiology of CVD. Succinate, as an https://doi.org/10.1093/cvr/cvx012
important metabolic intermediate and signaling molecule,
is a potential biomarker of cardiovascular disease. Further 4. Lussey-Lepoutre C, Hollinshead KE, Ludwig C. et al.,
studies on the biological function, signaling pathway, 2015, Loss of succinate dehydrogenase activity results
in dependency on pyruvate carboxylation for cellular
and regulatory mechanism of succinate may provide new anabolism. Nat Commun, 6: 8784.
strategies and targets for the diagnosis and treatment of
CVD in the coming era of precision medicine. https://doi.org/10.1038/ncomms9784
5. Burch JS, Marcero JR, Maschek JA, et al., 2018, Glutamine
Acknowledgments via alpha-ketoglutarate dehydrogenase provides succinyl-
We thank Manyuan Dong and Jianing Gao for reviewing CoA for heme synthesis during erythropoiesis. Blood,
132: 987–998.
the manuscript and providing comments.
https://doi.org/10.1182/blood-2018-01-829036
Funding 6. Winther S, Trauelsen M, Schwartz TW, 2021, Protective
This work was supported by the China Postdoctoral succinate-SUCNR1 metabolic stress signaling gone bad. Cell
Science Foundation Grant (No. 2021M700273). Metab, 33: 1276–1278.
https://doi.org/10.1016/j.cmet.2021.06.009
Conflict of interest
7. Martinez-Reyes I, Chandel NS, 2020, Mitochondrial TCA
The authors declare that they have no competing interest. cycle metabolites control physiology and disease. Nat
Commun, 11: 102.
Author contributions
https://doi.org/10.1038/s41467-019-13668-3
Conceptualization: Wenxin Shan, Hongtu Cui, and Lemin 8. Markevich NI, Galimova MH, Markevich LN, 2020,
Zheng Hysteresis and bistability in the succinate-CoQ reductase
Visualization: Yangkai Xu and Lemin Zheng activity and reactive oxygen species production in
Writing – original draft: Wenxin Shan, Hongtu Cui, and the mitochondrial respiratory complex II. Redox Biol,
Lemin Zheng 37: 101630.
Writing – review & editing: Jing Xue and Lemin Zheng https://doi.org/10.1016/j.redox.2020.101630
Ethics approval and consent to participate 9. Wagner M, Bertero E, Nickel A, et al., 2020, Selective NADH

Not applicable. communication from alpha-ketoglutarate dehydrogenase to
mitochondrial transhydrogenase prevents reactive oxygen
Consent for publication species formation under reducing conditions in the heart.
Basic Res Cardiol, 115: 53.
Not applicable.
https://doi.org/10.1007/s00395-020-0815-1
Availability of data 10. Liu PS, Wang H, Li X, et al., 2017, Alpha-ketoglutarate
Not applicable. orchestrates macrophage activation through metabolic and
epigenetic reprogramming. Nat Immunol, 18: 985–994.
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