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Global Translational Medicine Stem cells in aortic aneurysm

Table 1. Studies applying single‑cell RNA sequencing that reveals cell population of the aortic aneurysm
Species Diseases Number of Gender and Age (SD) Induction method Cell type Marker References
samples genotype
Mus AAA CaCl -induced Male 12 weeks CaCl -induced SMC Myh11, Acta2 [38]
2
2
musculus AAA and Sham, 4/ C57BL/6J mouse model EC Cdh5, Pecam1
group
Fibro Col1a1
Macro Lyz2
Neutr S100a8, S100a9
DC Klrd1, Flt3
T cell and NK Cd3g, Gzma
B cell Cd79a, Ms4a1
Mus AAA Days 7 and 14 post Male 10-week-old Elastase-perfusion SMC Myh11, Tagln, Acta2 [39]
musculus elastase-induced C57BL/6J mice perfused mouse model Fibro Dcn, Col1a1, Col3a1
AAA and Sham, 3/ for 7 or 14 days
group with elastase EC Cdh5, Pecam1, Fabp4
Mono/Macro Cd68, Cdca3, C1qb
B cell Cd79a, Ly6d, Cd79b
T cell Cd3d, Cd3g, Cd28
DC Cd209a, Ccr7, Ifitm1
Neural cell Prnp, Mpz
Eryth Bpgm, Snca, Hba-a1
Mus AAA 6 Ang II-induced Male ApoE −/− 8-week-old Ang II-infusion Fibro Col1a1 [40]
musculus AAA, 4 controls mice perfused mouse model SMC Acta2
for 28 days with
Ang II EC Pecam2
Macro Cd68
B cell Ms4a1
T cell Cd3e
Adipocyte Adipoq
Eryth Alas2
Mus AAA n=3 ApoE −/− 6–8-week-old Ang II-infusion Macro Cd11b, Cd68, Adgre1 [41]
musculus mice perfused mouse model T cell Cd3e
for 28 days with
Ang II B cell Cd19
Neutr Ly6g
DC Itgax
Mus AAA NA Male ApoE −/− 8-week-old Ang II-infusion Fibro Cd34, Pdgfra [42]
musculus mice perfused mouse model Macro Cd68, Ptprc
for 28 days with
Ang II SMC Acta2
EC Pecam1
T cell Cd3e, Cd8a
B cell Cd19
Lymphatic Lyve1, Pecam1
EC
Proliferating Top2a, Mki67
cell
Mus AAA NA Male ApoE −/− 12-week-old Ang II-infusion Fibro Col3a1, Col1a1, Dcn, [43]
musculus mice perfused mouse model Gsn
for 4 weeks with Mono/Macro Cd68, Aif1, C1qb
Ang II
(Cont’d...)
Volume 2 Issue 1 (2023) 5 https://doi.org/10.36922/gtm.v2i1.241