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Global Translational Medicine Stem cells in aortic aneurysm

Table 2. Animal models used in the treatment of AA involving stem cells
Cell type Delivery Injection time Number of AA model Total time Efficiency References
cells
BM-MSC IV injection Day 7771, 3, 3×10 /every Elastase-inducing 14 days Female MSC more strongly attenuate [100]
6
and 5 time mice AAA model AAA growth, and MSCs of different
sexes inhibit pro-inflammatory cytokines
at varying levels
UC-MSC IV injection Day 1 and 5 1×10 /every Elastase-inducing 14 days MSCs immunomodulate specific [62]
6
time mice TAA model microRNAs associated with modulating
hallmarks of aortic inflammation and
vascular remodeling of AA. So, it has the
potential to modulate TAA growth and
development using targeted therapies
designed with MSCs and miRNA
ADSC IV injection 2 h after 1×10 6 Elastase-inducing 14 days ADSCs ameliorate the progression [67]
inducing surgery mice AAA model of AAA by inducing a series of
anti-inflammatory cell events mediated
by parsecretory factors
UC-MSC IV injection Day 1 1×10 6 Elastase-inducing 14 days MSCs attenuate NADPH [101]
mice AAA model oxidase-dependent HMGB1 production
and inhibit AAA
Muse cells IV injection Day 0,7,14 20000/every Mice AA model by 3 or 8 weeks The significant attenuation of AA [92]
time incubation of and dilation was due to the spontaneous
elastase differentiation of Muse cells into VSMCs
and ECs, and the preservation of elastic
fibers
UC-MSC IV injection Day 1 1×10 6 Elastase-inducing 14 days UC-MSC attenuates AA dilation, [88]
mice AAA model decreases elastin degradation and
fragmentation, inhibits TNF-α and
MMP expression levels during initiation
and progression of AAA, and modulates
the biological role of VSMC contractile
phenotype
BM-MSC Endovascular 14 days after A total of The xenograft AAA 4 weeks BM-MSCs promote arterial regeneration [102]
seeding xenograft 1×10 6 rats model and functional recovery. Endovascular
implantation seeding of BM-MSCs stabilizes the
diameter of the already-dilated AAA
ASC ASC-loaded Immediately / Mice AAA model 2 weeks ASC-loaded RCP suppresses [103]
RCP after induction of by incubation of development and progression of AAA
AAA and elastase
ADSC Artery 4 weeks after 2×10 6 AAA rats model by 28 days ADSCs contribute to the reconstruction [104]
implantation the infiltration CaCl infiltration of elastic fibers by promoting the
2
operation secretion and synthesis of elastin in
SMCs
BM-MSC IV injection 28 days after 1×10 6 Ang II-infusion 2,4,8 weeks BM-MSCs reduce the incidence of AA, [105]
the infusion mouse model aortic diameter, the enzymatic activities
operation of MMP-2 and -9, downregulate
inflammatory cytokines, upregulate
IGF-1 and TIMP-2, and preserve the
construction of elastin
AD-MSC Catheter Day 5 1×10 6 Elastase-inducing 14 days Periadventitial stem cell delivery [95]
mice AAA model ameliorates elastase-induced AAA by
inhibiting aortic diameter dilatation and
reducing fragmented elastin
MSC-EV iv injection Day 1 1×10 6 Elastase-inducing 14 days MSC-EVs attenuate aortic inflammation [64]
mice AAA model and macrophage activation via
(Cont’d...)

Volume 2 Issue 1 (2023) 10 https://doi.org/10.36922/gtm.v2i1.241