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Global Translational Medicine New insights into chronic pain management

Figure 6. Study design and groups of patients in accordance with pain origin.

Figure 7. Incidence of depression (detected by HADS) and insomnia
(detected by DSM-5 clinical criteria) in patients with neuropathic and
nociceptive pain origins. P-values were obtained from Pearson’s Chi-
square test. Figure 9. Correlation of pain relief in age-stratified patient groups after
1 , 3 , and 12 week of vortioxetine treatment. P-values were obtained
st
th
rd
from Student’s t-tests.
Table 1. Correlation of pain relief with duration of pain,
origin of pain, and gender
Parameters Pain relief, mean mm Pain relief, mean mm
(1 week treatment) (12 week treatment)
st
th
Duration of pain (>12 2.36 versus 2.0, 3.72 versus 3.3,
months/≤12 months) P=0.279 P=0.45
Origin of pain 1.0 versus 0.82, 3.33 versus 3.59
(neuropathic and P=0.696 P=0.675
nociceptive)
Figure 8. Correlation of pain relief by visual analog scale depending on Gender (male and 1.17 versus 0.76, 4.17 versus 3.29,
presence of comorbid symptoms (clinical depression and insomnia). female) P=0.37 P=0.141
P-values were obtained from Student’s t-tests. P-values were obtained from Student’s t-tests.

comorbid symptoms such as depression and insomnia. The changes in the CNS participating in pain control and also
core of pathogenic mechanism of pain is the functional psychological, social and emotional stress, instead of organic

Volume 2 Issue 2 (2023) 6 https://doi.org/10.36922/gtm.312