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Global Translational Medicine                                        Epigenetics on cardiovascular diseases



            and the loss of human touch [155] . Importantly, significant   bring together diverse procedures to address uncertainties
            uncertainties still remain about how AI services will be   that have arisen in different specialized disciplines.
            adopted by health authorities and physicians for patients
            with chronic diseases such as CVDs. Moreover, the adoption   Acknowledgments
            of AI technology for complex interactive and integrative   This review paper was focused on the restricted field of
            epigenetic networks raises questions about cost, payments,   epigenetic perspective for atherosclerotic CVD patients
            reimbursement, and the  incremental value  provided by   and its connection with the holistic principle of systems
            AI systems. A significant issue arises concerning the use   biology. Unfortunately, we were unable to mention all
            of AI to solve scientific and social problems and improve   authors who published important and valuable work in the
            our lives. The Pew Research Center, which informs the   field of epigenetics due to limited space availability.
            public about the issues, attitudes, and trends shaping
            America and the world, published a report addressing the   Funding
            future of ethical AI. Based on a questionnaire addressed to   None.
            experts, the report concluded the following: “The majority
            worries that the evolution of AI by 2030 will continue to be   Conflict of interest
            primarily focused on optimizing profits and social control.
            They also cite the difficulty of achieving consensus about   The authors report that they have no financial or other
            ethics. Many who expect progress say it is not likely within   relations that could lead to a conflict of interest.
            the next decade. Still, a portion celebrates coming AI   Author contributions
            breakthroughs that will improve life.” [156]  Brender [157]  claims
            that physicians should grasp how to integrate AI tools into   Conceptualization: All authors
            clinical practice and be cautious of any new technology,   Writing – original draft: All authors
            especially one that carries existential implications. He   Writing – review & editing: All authors
            remarks that he is “prudently optimistic about a future
            of improved health-care system efficiency, better patient   Ethics approval and consent to participate
            outcomes, and reduced burnout.”                    Not applicable.

            6. Conclusion                                      Consent for publication
            Complex diseases, such as CVDs, result from a combination   Not applicable.
            of genetic and environmental components. Epigenetic
            modifications are highly influenced by the environment,   Availability of data
            and throughout an  individual’s lifetime,  exposure  to   Not applicable.
            environmental  risk  factors  increases  the  occurrence
            of CVDs later in life. On an individual basis, everyone   References
            should be part of a program that provides improved food   1.   Cox D, 2023, The Mystery of the Human Genome’s Dark
            quality with reduced exposure to air pollution and other   Matter. United Kingdom: Future-BBC.
            contaminants. Epigenetic regulation of genes associated
            with  the  atherosclerotic  process  is  crucial.  The  interplay   2.   Fasolo  F,  Di  Gregoli  K,  Maegdefessel L,  et al.,  2019,
            between various epigenetic factors is key to understanding   Non-coding RNAs in cardiovascular cell biology and
                                                                  atherosclerosis. Cardiovasc Res, 115: 1732–1756.
            the complexity of the atherosclerotic process and increases
            the probability of expanding our knowledge, thereby aiding      https://doi.org/10.1093/cvr/cvz203
            in the prevention and treatment of patients with CVDs. The   3.   Rizzacasa B, Amati F, Romeo F,  et al., 2019, Epigenetic
            SB methodology of network-based processes has emerged   modification in coronary atherosclerosis: JACC review topic
            as a dynamic tool for studying complex CVDs. Scientific   of the week. J Am Coll Cardiol, 74: 1352–1365.
            cooperation is essential for the productive implementation      https://doi.org/10.1016/j.jacc.2019.07.043
            of  the  SB  holistic  understanding  in  epigenetic  research
            and clinical thinking. A  suitable digital project could   4.   Alghamdi BA, Aljohani IM, Alotaibi BG,  et al., 2022,
            be  undertaken  to explore and  interconnect epigenetic   Studying epigenetics of cardiovascular diseases on chip
                                                                  guide. Cardiogenetics, 12: 218–234.
            factors with biological or disease networks and clinical
            phenotypes. This project, run by a powerful computational      https://doi.org/10.3390/cardiogenetics12030021
            program, should serve as an interdisciplinary mechanism   5.   Koch L, 2023, Spatial epigenomics in single cells. Nat Rev
            involving the scientific community as a whole. It should   Genet, 24: 1.


            Volume 2 Issue 4 (2023)                         14                       https://doi.org/10.36922/gtm.1868
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