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Global Translational Medicine Epigenetics on cardiovascular diseases
and the loss of human touch [155] . Importantly, significant bring together diverse procedures to address uncertainties
uncertainties still remain about how AI services will be that have arisen in different specialized disciplines.
adopted by health authorities and physicians for patients
with chronic diseases such as CVDs. Moreover, the adoption Acknowledgments
of AI technology for complex interactive and integrative This review paper was focused on the restricted field of
epigenetic networks raises questions about cost, payments, epigenetic perspective for atherosclerotic CVD patients
reimbursement, and the incremental value provided by and its connection with the holistic principle of systems
AI systems. A significant issue arises concerning the use biology. Unfortunately, we were unable to mention all
of AI to solve scientific and social problems and improve authors who published important and valuable work in the
our lives. The Pew Research Center, which informs the field of epigenetics due to limited space availability.
public about the issues, attitudes, and trends shaping
America and the world, published a report addressing the Funding
future of ethical AI. Based on a questionnaire addressed to None.
experts, the report concluded the following: “The majority
worries that the evolution of AI by 2030 will continue to be Conflict of interest
primarily focused on optimizing profits and social control.
They also cite the difficulty of achieving consensus about The authors report that they have no financial or other
ethics. Many who expect progress say it is not likely within relations that could lead to a conflict of interest.
the next decade. Still, a portion celebrates coming AI Author contributions
breakthroughs that will improve life.” [156] Brender [157] claims
that physicians should grasp how to integrate AI tools into Conceptualization: All authors
clinical practice and be cautious of any new technology, Writing – original draft: All authors
especially one that carries existential implications. He Writing – review & editing: All authors
remarks that he is “prudently optimistic about a future
of improved health-care system efficiency, better patient Ethics approval and consent to participate
outcomes, and reduced burnout.” Not applicable.
6. Conclusion Consent for publication
Complex diseases, such as CVDs, result from a combination Not applicable.
of genetic and environmental components. Epigenetic
modifications are highly influenced by the environment, Availability of data
and throughout an individual’s lifetime, exposure to Not applicable.
environmental risk factors increases the occurrence
of CVDs later in life. On an individual basis, everyone References
should be part of a program that provides improved food 1. Cox D, 2023, The Mystery of the Human Genome’s Dark
quality with reduced exposure to air pollution and other Matter. United Kingdom: Future-BBC.
contaminants. Epigenetic regulation of genes associated
with the atherosclerotic process is crucial. The interplay 2. Fasolo F, Di Gregoli K, Maegdefessel L, et al., 2019,
between various epigenetic factors is key to understanding Non-coding RNAs in cardiovascular cell biology and
atherosclerosis. Cardiovasc Res, 115: 1732–1756.
the complexity of the atherosclerotic process and increases
the probability of expanding our knowledge, thereby aiding https://doi.org/10.1093/cvr/cvz203
in the prevention and treatment of patients with CVDs. The 3. Rizzacasa B, Amati F, Romeo F, et al., 2019, Epigenetic
SB methodology of network-based processes has emerged modification in coronary atherosclerosis: JACC review topic
as a dynamic tool for studying complex CVDs. Scientific of the week. J Am Coll Cardiol, 74: 1352–1365.
cooperation is essential for the productive implementation https://doi.org/10.1016/j.jacc.2019.07.043
of the SB holistic understanding in epigenetic research
and clinical thinking. A suitable digital project could 4. Alghamdi BA, Aljohani IM, Alotaibi BG, et al., 2022,
be undertaken to explore and interconnect epigenetic Studying epigenetics of cardiovascular diseases on chip
guide. Cardiogenetics, 12: 218–234.
factors with biological or disease networks and clinical
phenotypes. This project, run by a powerful computational https://doi.org/10.3390/cardiogenetics12030021
program, should serve as an interdisciplinary mechanism 5. Koch L, 2023, Spatial epigenomics in single cells. Nat Rev
involving the scientific community as a whole. It should Genet, 24: 1.
Volume 2 Issue 4 (2023) 14 https://doi.org/10.36922/gtm.1868

