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Global Translational Medicine                                    Open carpal tunnel release surgical outcomes



            surgical outcomes of OCTR among CTS patients seeking   Our study observed that 5.9% of patients presented with
            treatment at Zliten Teaching Hospital.             recurrent symptoms, and 1.5% experienced persistent
              In general, the implementation of OCTR procedures   symptoms even after the operation. A  large-scale study
            in CTS patients yielded favorable results during the   involving 2053 open carpal tunnel decompressions
            post-operative follow-up. Surgical and post-surgical   revealed that only 34  patients (1.6% of cases) required
                                                                                                   [21]
            photographs of the hand of a female patient are presented   re-exploration  due  to  symptom  recurrence .  However,
            for reference in Figures 1 and 2, respectively.    it is worth noting that contrasting findings have been
                                                               reported in other studies, with recurrent symptoms of
              Approximately 9.4% of our study participants     CTS in approximately 19% of patients following OCTR,
            experienced postoperative complications, while 90.6%   with up to 12% requiring re-exploration [18,22-24] . A  study
            were highly satisfied with the results of the open release,   conducted in Iran reported an incidence of 12.4%
            reporting no recurrence symptoms. The review by    for recurrent CTS and 10.4% for persistent CTS after
            Kuschner et al. noted an overall complication rate ranging   OCTR . Furthermore, other studies have reported that
                                                                    [18]
            from 1% to 2% . In a study by Kulick et al., 4.6% of 130   these symptoms can persist or recur in up to 30% of
                        [19]
            hands treated with the open release technique developed   cases following surgery, and such cases are more likely to
            recurrent symptoms during post-operative follow-up .   develop post-operative complications [24,25] . Therefore, it is
                                                        [20]
                                                               evident that several patients prefer conservative treatments
                                                               over surgical procedures due to their minimally invasive
                                                               nature . A previous study has documented several post-
                                                                    [26]
                                                               surgical adverse effects,  including  infections,  painful  or
                                                               hypertrophic scars, wound hematomas, edema, wrist
                                                               discomfort,  stiffness,  and  reflex  sympathetic  dystrophy,
                                                               affecting approximately 56.6% of CTS patients . In
                                                                                                        [27]
                                                               comparison, our study identified only 2% of patients
                                                               presenting with superficial wound infections, indicative of
                                                               effective post-operative management by the hospital staff
                                                               while treating the patients. The correlation between post-
                                                               operative complications, symptom persistence, and partial
                                                               median nerve  decompression has  been noted . These
                                                                                                     [18]
                                                               findings support the effectiveness of our surgical strategy,
                                                               contributing to the low complication and recurrence rates
                                                               observed in our study. It is important to recognize that an
            Figure 1. A photograph of the hand of a 53-year-old female patient with   increased incidence of complications and recurrence of
            hyperemic median nerve during an open carpal tunnel release surgical   symptoms occur after surgical failures, primarily attributed
            procedure.
                                                               to diagnostic errors in the cases involving double crush in
                                                               nerve entrapment syndromes, median nerve tumors, and
                                                               iatrogenic injuries .
                                                                             [28]
                                                                 The discrepancy observed in the outcomes of
                                                               various studies can be attributed to the demographic
                                                               characteristics of the study participants. The previous
                                                               literature has indicated that CTS is more prevalent among
                                                               specific demographic groups, including women, obese
                                                               individuals  and middle-aged individuals , those with
                                                                                                  [14]
                                                                        [15]
                                                               metabolic and degenerative conditions , and certain
                                                                                                [5]
                                                               occupational groups with repetitive wrist movements .
                                                                                                           [29]
                                                               For instance, a review article discussed a study involving
                                                               60 patients treated with the open release technique, reporting
                                                               that only one patient required CTS revision surgery during
                                                               a mean follow-up period of 5.5 years . In contrast, our
                                                                                             [30]
                                                               study reported three revision operations within a 2-year
            Figure 2. A photograph of the hand of the patient post-surgery (1-year   follow-up period. The primary factors contributing to CTS
            follow-up).                                        recurrence included inadequate surgical skill, incorrect

            Volume 2 Issue 4 (2023)                         6                        https://doi.org/10.36922/gtm.1019
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