Page 25 - GTM-3-1

Global Translational Medicine Role of HTS in cancer therapeutics

66. Beck V, Pfitscher A, Jungbauer A. GFP‑reporter for a 77. Zlitni S, Blanchard JE, Brown ED. High‑throughput screening
high throughput assay to monitor estrogenic compounds. of model bacteria. Methods Mol Biol. 2009;486:13‑27.
J Biochem Biophys Methods. 2005;64(1):19‑37.
78. Hong CC. Large‑scale small‑molecule screen using zebrafish
doi: 10.1016/j.jbbm.2005.05.001 embryos. Methods Mol Biol. 2009;486:43‑55.
67. Yarrow JC, Totsukawa G, Charras GT, Mitchison TJ. doi: 10.1007/978‑1‑60327‑545‑3_4
Screening for cell migration inhibitors via automated
microscopy reveals a Rho-kinase inhibitor. Chem Biol. 79. Zon LI, Peterson RT. In vivo drug discovery in the zebrafish.
2005;12(3):385‑395. Nat Rev Drug Discov. 2005;4(1):35‑44.
doi: 10.1016/j.chembiol.2005.01.015 doi: 10.1038/nrd1606
68. Vincent F, Loria P, Pregel M, et al. Developing predictive 80. O’Rourke EJ, Conery AL, Moy TI. Whole‑animal high‑
assays: The phenotypic screening “rule of 3”. Sci Transl Med. throughput screens: The C. elegans model. Methods Mol Biol.
2015;7(293):293ps15. 2009;486:57‑75.
doi: 10.1126/scitranslmed.aab1201 doi: 10.1007/978‑1‑60327‑545‑3_5
69. Engle SJ, Vincent F. Small molecule screening in human 81. Agee A, Carter D. Whole‑organism screening: Plants.
induced pluripotent stem cell-derived terminal cell types. Methods Mol Biol. 2009;486:77‑95.
J Biol Chem. 2014;289(8):4562‑4570. doi: 10.1007/978‑1‑60327‑545‑3_6
doi: 10.1074/jbc.R113.529156 82. Norambuena L, Raikhel NV, Hicks GR. Chemical genomics
70. McNeish J, Roach M, Hambor J, et al. High-throughput approaches in plant biology. Plant Syst Biol. 2009;553:345‑354.
screening in embryonic stem cell-derived neurons doi: 10.1007/978‑1‑60327‑563‑7_18
identifies potentiators of α-amino-3-hydroxyl-5-methyl-4-
isoxazolepropionate-type glutamate receptors. J Biol Chem. 83. Stern HM, Murphey RD, Shepard JL, et al. Small molecules
2010;285(22):17209‑17217. that delay S phase suppress a zebrafish bmyb mutant. Nat
Chem Biol. 2005;1(7):366‑370.
doi: 10.1074/jbc.M109.098814
doi: 10.1038/nchembio749
71. Ashlock MA, Olson ER. Therapeutics development for
cystic fibrosis: A successful model for a multisystem genetic 84. Hong CC, Peterson QP, Hong JY, Peterson RT. Artery/vein
disease. Annu Rev Med. 2011;62:107‑125. specification is governed by opposing phosphatidylinositol-3 kinase
and MAP kinase/ERK signaling. Curr Biol. 2006;16(13):1366‑1372.
doi: 10.1146/annurev‑med‑061509‑131034
doi: 10.1016/j.cub.2006.05.046
72. Van Goor F, Hadida S, Grootenhuis PDJ, et al. Correction
of the F508del‑CFTR protein processing defect in vitro by 85. Swinney DC. The value of translational biomarkers to
the investigational drug VX‑809. Proc Natl Acad Sci U S A. phenotypic assays. Front Pharmacol. 2014;5:171.
2011;108(46):18843‑18848.
doi: 10.3389/fphar.2014.00171
doi: 10.1073/pnas.1105787108
86. Ioannidis JP. Biomarker failures. Clin Chem. 2013;59(1):202‑204.
73. Lee G, Ramirez CN, Kim H, et al. Large‑scale screening
using familial dysautonomia induced pluripotent stem cells doi: 10.1373/clinchem.2012.185801
identifies compounds that rescue IKBKAP expression. Nat 87. Chau CH, Rixe O, McLeod H, Figg WD. Validation of
Biotechnol. 2012;30(12):1244‑1248. analytic methods for biomarkers used in drug development.
doi: 10.1038/nbt.2435 Clin Cancer Res. 2008;14(19):5967‑5976.
74. Barberis A, Gunde T, Berset C, Audetat S, Lüthi U. Yeast as a doi: 10.1158/1078‑0432.Ccr‑07‑4535
screening tool. Drug Discov Today Technol. 2005;2(2):187‑192. 88. Spreafico R, Soriaga LB, Grosse J, Virgin HW, Telenti A.
doi: 10.1016/j.ddtec.2005.05.022 Advances in genomics for drug development. Genes (Basel).
2020;11(8):942.
75. Balgi AD, Roberge M. Screening for chemical inhibitors
of heterologous proteins expressed in yeast using a simple doi:10.3390/genes11080942
growth-restoration assay. Methods Mol Biol. 2009;486:125‑137. 89. Guo JB, Li XJ. Impacts of modern biology on drug discovery.
doi: 10.1007/978‑1‑60327‑545‑3_9 Sheng Li Ke Xue Jin Zhan. 2007;38(1):25‑31.
76. Puri AW, Bogyo M. Using small molecules to dissect 90. Hong AL, Tseng YY, Cowley GS, et al. Integrated genetic and
mechanisms of microbial pathogenesis. ACS Chem Biol. pharmacologic interrogation of rare cancers. Nat Commun.
2009;4(8):603‑616. 2016;7:11987.
doi: 10.1021/cb9001409 doi: 10.1038/ncomms11987

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