Page 38 - GTM-3-2
P. 38
Global Translational Medicine Impact of flavonoids on vascular health
68. Lebas H, Yahiaoui K, Martos R, Boulaftali Y. Platelets are at the quality of life in post-myocardial infarction patients:
nexus of vascular diseases. Front Cardiovasc Med. 2019;6:132. A double blind, placebo-controlled, randomized clinical
trial. Phytother Res. 2021;35(4):2085-2098.
doi: 10.3389/fcvm.2019.00132
doi: 10.1002/ptr.6955
69. Kannan M, Ahmad F, Saxena R. Platelet activation markers
in evaluation of thrombotic risk factors in various clinical 80. Dower JI, Geleijnse JM, Gijsbers L, Zock PL, Kromhout D,
settings. Blood Rev. 2019;37:100583. Hollman PC. Effects of the pure flavonoids epicatechin and
quercetin on vascular function and cardiometabolic health:
doi: 10.1016/j.blre.2019.05.007
A randomized, double-blind, placebo-controlled, crossover
70. Braune S, Küpper JH, Jung F. Effect of prostanoids on human trial. Am J Clin Nutr. 2015;101(5):914-921.
platelet function: An overview. Int J Mol Sci. 2020;21(23):9020.
doi: 10.3945/ajcn.114.098590
doi: 10.3390/ijms21239020
81. Edwards RL, Lyon T, Litwin SE, Rabovsky A, Symons JD,
71. Ciumărnean L, Milaciu MV, Runcan O, et al. The effects Jalili T. Quercetin reduces blood pressure in hypertensive
of flavonoids in cardiovascular diseases. Molecules. subjects. J Nutr. 2007;137(11):2405-2411.
2020;25(18):4320.
doi: 10.1093/jn/137.11.2405
doi: 10.3390/molecules25184320
82. Nishihira J, Nishimura M, Kurimoto M, et al. The effect of
72. Hong HJ, Nam GS, Nam KS. Daidzein inhibits human 24-week continuous intake of quercetin-rich onion on age-
platelet activation by downregulating thromboxane A(2) related cognitive decline in healthy elderly people: A randomized,
production and granule release, regardless of COX-1 double-blind, placebo-controlled, parallel-group comparative
activity. Int J Mol Sci. 2023;24(15):11985. clinical trial. J Clin Biochem Nutr. 2021;69(2):203-215.
doi: 10.3390/ijms241511985 doi: 10.3164/jcbn.21-17
73. Sharifi-Rad J, Quispe C, Shaheen S, et al. Flavonoids as 83. Shatylo V, Antoniuk-Shcheglova I, Naskalova S, et al.
potential anti-platelet aggregation agents: from biochemistry Cardio-metabolic benefits of quercetin in elderly patients
to health promoting abilities. Crit Rev Food Sci Nutr. with metabolic syndrome. Pharma Nutr. 2021;15:100250.
2022;62(29):8045-8058.
doi: 10.1016/j.phanu.2020.100250
doi: 10.1080/10408398.2021.1924612
84. Shi Y, Williamson G. Quercetin lowers plasma uric acid
74. Oh TW, Do HJ, Jeon JH, Kim K. Quercitrin inhibits in pre-hyperuricaemic males: A randomised, double-
platelet activation in arterial thrombosis. Phytomedicine. blinded, placebo-controlled, cross-over trial. Br J Nutr.
2021;80:153363. 2016;115(5):800-806.
doi: 10.1016/j.phymed.2020.153363 doi: 10.1017/s0007114515005310
75. Zaragozá C, Monserrat J, Mantecón C, et al. Binding and 85. Ali F, Wang D, Cheng Y, et al. Quercetin attenuates
antiplatelet activity of quercetin, rutin, diosmetin, and angiotensin II-induced proliferation of vascular smooth
diosmin flavonoids. Biomed Pharmacother. 2021;141:111867. muscle cells and p53 pathway activation in vitro and in vivo.
BioFactors. 2023;49(4):956-970.
doi: 10.1016/j.biopha.2021.111867
doi: 10.1002/biof.1959
76. Oh YS. Arterial stiffness and hypertension. Clin Hypertens.
2018;24(1):17. 86. Gallo EF, Iadecola C. Neuronal nitric oxide contributes
to neuroplasticity-associated protein expression through
doi: 10.1186/s40885-018-0102-8
cGMP, protein kinase G, and extracellular signal-regulated
77. Papathanasiou G, Zerva E, Zacharis I, et al. Association of kinase. J Neurosci. 2011;31(19):6947-6955.
high blood pressure with body mass index, smoking and
physical activity in healthy young adults. Open Cardiovasc doi: 10.1523/jneurosci.0374-11.2011
Med J. 2015;9:5-17. 87. Wojta J. Vascular smooth muscle cells: Regulation of
vasoconstriction and vasodilation. In: Geiger M, editor.
doi: 10.2174/1874192401509010005
Fundamentals of Vascular Biology. Germany: Springer
78. Bian K, Doursout MF, Murad F. Vascular system: Role of International Publishing; 2019. p. 97-111.
nitric oxide in cardiovascular diseases. J Clin Hypertens 88. De Souza P, da Silva LM, de Andrade SF, Gasparotto A Jr.
(Greenwich). 2008;10(4):304-310.
Recent advances in the knowledge of naturally-derived
doi: 10.1111/j.1751-7176.2008.06632.x bioactive compounds as modulating agents of the renin-
angiotensin-aldosterone system: Therapeutic benefits in
79. Dehghani F, Sezavar Seyedi Jandaghi SH, Janani L,
Sarebanhassanabadi M, Emamat H, Vafa M. Effects of cardiovascular diseases. Curr Pharm Des. 2019;25(6):670-684.
quercetin supplementation on inflammatory factors and doi: 10.2174/1381612825666190329122443
Volume 3 Issue 2 (2024) 18 doi: 10.36922/gtm.2458

