Page 39 - GTM-3-2

Global Translational Medicine Impact of flavonoids on vascular health

89. Te Riet L, van Esch JH, Roks AJ, van den Meiracker AH, 100. Egert S, Bosy-Westphal A, Seiberl J, et al. Quercetin reduces
Danser AH. Hypertension: renin-angiotensin-aldosterone systolic blood pressure and plasma oxidised low-density
system alterations. Circ Res. 2015;116(6):960-975. lipoprotein concentrations in overweight subjects with
a high-cardiovascular disease risk phenotype: A double-
doi: 10.1161/circresaha.116.303587
blinded, placebo-controlled cross-over study. Br J Nutr.
90. Hall JE, Do Carmo JM, da Silva AA, Wang Z, Hall ME. 2009;102(7):1065-1074.
Obesity, kidney dysfunction and hypertension: mechanistic
links. Nat Rev Nephrol. 2019;15(6):367-385. doi: 10.1017/S0007114509359127
doi: 10.1038/s41581-019-0145-4 101. Lee KH, Park E, Lee HJ, et al. Effects of daily quercetin-
rich supplementation on cardiometabolic risks in male
91. Verma N, Rastogi S, Chia YC, et al. Non-pharmacological smokers. NRP. 2011;5(1):28-33.
management of hypertension. J Clin Hypertens (Greenwich).
2021;23(7):1275-1283. doi: 10.4162/nrp.2011.5.1.28
doi: 10.1111/jch.14236 102. Larson A, Witman MA, Guo Y, et al. Acute, quercetin-
induced reductions in blood pressure in hypertensive
92. Siervo M, Lara J, Chowdhury S, Ashor A, Oggioni C, Mathers individuals are not secondary to lower plasma angiotensin-
JC. Effects of the dietary approach to stop hypertension converting enzyme activity or endothelin-1: Nitric oxide.
(DASH) diet on cardiovascular risk factors: A systematic Nutr Res. 2012;32(8):557-564.
review and meta-analysis. Br J Nutr. 2015;113(1):1-15.
doi: 10.1016/j.nutres.2012.06.018
doi: 10.1017/s0007114514003341
103. Huang H, Liao D, Dong Y, Pu R. Effect of quercetin
93. Ellwood L, Torun G, Bahar Z, Fernandez R. Effects of flavonoid- supplementation on plasma lipid profiles, blood pressure,
rich fruits on hypertension in adults: A systematic review. JBI and glucose levels: A systematic review and meta-analysis.
Database Syst Rev Implement Rep. 2019;17(10):2075-2105. Nutr Rev. 2020;78(8):615-626.
doi: 10.11124/jbisrir-d-19-00050 doi: 10.1093/nutrit/nuz071

94. Zięba K, Makarewicz-Wujec M, Kozłowska- 104. Serban MC, Sahebkar A, Zanchetti A, et al. Effects of
Wojciechowska M. Cardioprotective mechanisms of cocoa. quercetin on blood pressure: A systematic review and
J Am Coll Nutr. 2019;38(6):564-575. meta‐analysis of randomized controlled trials. J Am Heart
doi: 10.1080/07315724.2018.1557087 Assoc. 2016;5(7):e002713.
95. Gai Z, Hu S, Gong G, Zhao J. Recent advances in doi: 10.1161/JAHA.115.002713
understanding dietary polyphenols protecting against 105. Vogiatzoglou A, Mulligan AA, Lentjes MA, et al. Flavonoid
hypertension. Trends Food Sci Technol. 2023;138:685-696. intake in European adults (18 to 64 years). PLoS One.
doi: 10.1016/j.tifs.2023.07.008 2015;10(5):e0128132.
96. Clark JL, Zahradka P, Taylor CG. Efficacy of flavonoids doi: 10.1371/journal.pone.0128132
in the management of high blood pressure. Nutr Rev. 106. Perez A, Gonzalez-Manzano S, Jimenez R, et al. The
2015;73(12):799-822. flavonoid quercetin induces acute vasodilator effects in
doi: 10.1093/nutrit/nuv048 healthy volunteers: Correlation with beta-glucuronidase
activity. Pharmacol Res. 2014;89:11-18.
97. Syed AA, Lahiri S, Mohan D, et al. Evaluation of anti-
hypertensive activity of Ulmus wallichiana extract and doi: 10.1016/j.phrs.2014.07.005
fraction in SHR, DOCA-salt- and L-NAME-induced 107. Papakyriakopoulou P, Velidakis N, Khattab E, Valsami G,
hypertensive rats. J Ethnopharmacol. 2016;193:555-565. Korakianitis I, Kadoglou NP. Potential pharmaceutical
doi: 10.1016/j.jep.2016.10.008 applications of quercetin in cardiovascular diseases.
Pharmaceuticals (Basel). 2022;15(8):1019.
98. Mzhelskaya KV, Shipelin VA, Shumakova AA, et al. Effects
of quercetin on the neuromotor function and behavioral doi: 10.3390/ph15081019
responses of Wistar and Zucker rats fed a high-fat and high- 108. Gómez-Guzmán M, Jiménez R, Sánchez M, et al.
carbohydrate diet. Behav Brain Res. 2020;378:112270. Epicatechin lowers blood pressure, restores endothelial
doi: 10.1016/j.bbr.2019.112270 function, and decreases oxidative stress and endothelin-1
and NADPH oxidase activity in DOCA-salt hypertension.
99. Carresi C, Cardamone A, Coppoletta AR, et al. The protective
effect of Bergamot Polyphenolic Fraction on reno-cardiac Free Radic Biol Med. 2012;52(1):70-79.
damage induced by DOCA-salt and unilateral renal artery doi: 10.1016/j.freeradbiomed.2011.09.015
ligation in rats. Biomed Pharmacother. 2024;171:116082.
109. Connolly K, Batacan R, Jackson D, Fenning AS. Effects
doi: 10.1016/j.biopha.2023.116082 of epicatechin on cardiovascular function in middle-aged

Volume 3 Issue 2 (2024) 19 doi: 10.36922/gtm.2458