Page 41 - GTM-3-2

Global Translational Medicine Impact of flavonoids on vascular health

doi: 10.1002/ptr.6991 doi: 10.1016/j.jnutbio.2010.02.008
131. Yang Y, Trevethan M, Wang S, Zhao L. Beneficial effects of 139. Wang S, Zhang X, Liu M, et al. Chrysin inhibits foam cell
citrus flavanones naringin and naringenin and their food formation through promoting cholesterol efflux from
sources on lipid metabolism: An update on bioavailability, RAW264.7 macrophages. Pharm Biol. 2015;53(10):1481-1487.
pharmacokinetics, and mechanisms. J Nutr Biochem. doi: 10.3109/13880209.2014.986688
2022;104:108967.
140. Lian Z, Zhu B, Lei C, et al. Reverse cholesterol transport-
doi: 10.1016/j.jnutbio.2022.108967 related miRNAs and their regulation by natural functional
132. Mohammed CJ, Lamichhane S, Connolly JA, et al. A PON compounds. Curr Protein Pept Sci. 2019;20(10):1004-1011.
for all seasons: Comparing paraoxonase enzyme substrates, doi: 10.2174/1389203720666190827143218
activity and action including the role of PON3 in health
and disease. Antioxidants (Basel). 2022;11(3):590. 141. Rangarajan S, Orujyan D, Rangchaikul P, Radwan MM.
Critical role of inflammation and specialized pro-
doi: 10.3390/antiox11030590 resolving mediators in the pathogenesis of atherosclerosis.
133. Ghahremani S, Soodi M, Atashi A. Quercetin ameliorates Biomedicines. 2022;10(11):2829.
chlorpyrifos-induced oxidative stress in the rat brain: doi: 10.3390/biomedicines10112829
Possible involvment of PON2 pathway. J Food Biochem.
2018;42(3):e12530. 142. Vernocchi P, Del Chierico F, Putignani L. Gut microbiota
metabolism and interaction with food components. Int J
doi: 10.1111/jfbc.12530 Mol Sci. 2020;21(10):3688.
134. Ibrahim KA, Eleyan M, Khwanes SA, Mohamed RA, doi: 10.3390/ijms21103688
Abd El-Rahman HA. Quercetin ameliorates the hepatic
apoptosis of foetal rats induced by in utero exposure 143. Zhen J, Zhou Z, He M, et al. The gut microbial metabolite
to fenitrothion via the transcriptional regulation of trimethylamine N-oxide and cardiovascular diseases. Front
paraoxonase-1 and apoptosis-related genes. Biomarkers. Endocrinol (Lausanne). 2023;14:1085041.
2021;26(2):152-162. doi: 10.3389/fendo.2023.1085041
doi: 10.1080/1354750X.2021.1875505 144. Ren D, Liu Y, Zhao Y, Yang X. Hepatotoxicity and
135. Deng Q, Li XX, Fang Y, Chen X, Xue J. Therapeutic endothelial dysfunction induced by high choline diet and
potential of quercetin as an antiatherosclerotic agent in the protective effects of phloretin in mice. Food Chem
atherosclerotic cardiovascular disease: A review. Evid Toxicol. 2016;94:203-212.
Based Complement Altern Med. 2020;2020:5926381. doi: 10.1016/j.fct.2016.06.004
doi: 10.1155/2020/5926381 145. Pfeuffer M, Auinger A, Bley U, et al. Effect of quercetin on
136. Peters LJ, Biessen EA, Hohl M, Weber C, van der Vorst EP, traits of the metabolic syndrome, endothelial function and
Santovito D. Small things matter: Relevance of MicroRNAs inflammation in men with different APOE isoforms. Nutr
in cardiovascular disease. Front Physiol. 2020;11:793. Metab Cardiovasc Dis. 2013;23(5):403-409.
doi: 10.3389/fphys.2020.00793 doi: 10.1016/j.numecd.2011.08.010
137. Luo HY, Li G, Liu YG, et al. The accelerated progression 146. Curtis PJ, Potter J, Kroon PA, et al. Vascular function and
of atherosclerosis correlates with decreased miR-33a atherosclerosis progression after 1 y of flavonoid intake
and miR-21 and increased miR-122 and miR-3064-5p in in statin-treated postmenopausal women with type 2
circulation and the liver of ApoE-/-mice with streptozocin diabetes: A double-blind randomized controlled trial. Am J
(STZ)-induced type 2 diabetes. Curr Issues Mol Biol. Clin Nutr. 2013;97(5):936-942.
2022;44(10):4822-4837. doi: 10.3945/ajcn.112.043745
doi: 10.3390/cimb44100328 147. Zhu Y, Ling W, Guo H, et al. Anti-inflammatory
effect of purified dietary anthocyanin in adults with
138. Boesch-Saadatmandi C, Loboda A, Wagner AE, et al.
Effect of quercetin and its metabolites isorhamnetin and hypercholesterolemia: A randomized controlled trial. Nutr
quercetin-3-glucuronide on inflammatory gene expression: Metab Cardiovasc Dis. 2013;23(9):843-849.
role of miR-155. J Nutr Biochem. 2011;22(3):293-299. doi: 10.1016/j.numecd.2012.06.005

Volume 3 Issue 2 (2024) 21 doi: 10.36922/gtm.2458