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Global Translational Medicine SLE patient underwent PD

A B

C D

E F

Figure 3. Specific immune landscape in this case compared with public datasets. (A) CIBERSORT immune cell infiltrate analysis showing the absolute
fraction (%)±SD of different immune cell subsets within pancreatic tumors in the TCGA dataset, and (B) in the PACA-AU dataset, compared with those
in this case. (C) CIBERSORT immune cell infiltrate analysis showing the absolute fraction (%)±SD of different immune cell subsets within lymph nodes
in the GSE103787 dataset compared with those in this case. (D-F) Expression levels of different cytotoxic markers in tumors or lymph nodes within the
TCGA, PACA-AU, or GSE103787 datasets compared with those in this case, based on sequencing data.
Abbreviations: SD: Standard deviation; TCGA: The cancer genome atlas.

following previously described procedures. Furthermore, 3. Discussion
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we examined the protein expression of GZMB and PRF1
in the Human Protein Atlas immunohistochemical Our case demonstrates the feasibility of performing a
staining databases and found that both GZMB and PD in a SLE patient who had previously undergone renal
PRF1 were negative in pancreatic tumor tissues (11/11 transplantation. At present, surgery remains the only
and 12/12 samples, respectively). Representative images potentially curative therapeutic strategy available for
(patient ID: 834) are shown in Figure 4B. pancreatic cancer, but its complicated procedure and the
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Volume 3 Issue 3 (2024) 4 doi: 10.36922/gtm.2893