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Global Translational Medicine Metabolic dysfunction in vascular senescence

or neurodegenerative diseases, treatment complexity Consent for publication
substantially increases. For instance, patients with diabetes may
experience reduced effectiveness of standard antihypertensive Not applicable.
treatments because of endothelial dysfunction and chronic Availability of data
inflammation. Furthermore, the accumulation of advanced
75
glycation end products triggers oxidative stress. When Not applicable.
cardiovascular diseases coexist with neurodegenerative References
diseases (e.g., Alzheimer’s disease), there is a synergistic
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Funding
5. Roger L, Tomas F, Gire V. Mechanisms and regulation of
This work was supported by a grant from the National cellular senescence. Int J Mol Sci. 2021;22(23):13173.
Key Research and Development Program of China doi: 10.3390/ijms222313173
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Author contributions doi: 10.1038/s41392-023-01502-8

Conceptualization: Ying Qu, Baoqi Yu 9. Erusalimsky JD, Kurz DJ. Endothelial cell senescence.
Visualization: Anan Wang, Caihua Long Handb Exp Pharmacol. 2006;(176 Pt 2):213-248.
Writing – original draft: Ying Qu, Baoqi Yu doi: 10.1007/3-540-36028-x_7
Writing – review & editing: Ying Qu, Qiuyue Gao, Baoqi Yu 10. Ritschka B, Storer M, Mas A, et al. The senescence-associated
secretory phenotype induces cellular plasticity and tissue
Ethics approval and consent to participate regeneration. Genes Dev. 2017;31(2):172-183.
Not applicable. doi: 10.1101/gad.290635.116

Volume 3 Issue 4 (2024) 10 doi: 10.36922/gtm.4619