Page 31 - GTM-3-4
P. 31
Global Translational Medicine Metabolic dysfunction in vascular senescence
11. Bloom SI, Islam MT, Lesniewski LA, Donato AJ. Mechanisms 23. Morrison SJ, Spradling AC. Stem cells and niches:
and consequences of endothelial cell senescence. Nat Rev Mechanisms that promote stem cell maintenance throughout
Cardiol. 2023;20(1):38-51. life. Cell. 2008;132(4):598-611.
doi: 10.1038/s41569-022-00739-0 doi: 10.1016/j.cell.2008.01.038
12. Libby P, Buring JE, Badimon L, et al. Atherosclerosis. Nat 24. Neves J, Sousa-Victor P, Jasper H. Rejuvenating strategies
Rev Dis Primers. 2019;5(1):56. for stem cell-based therapies in aging. Cell Stem Cell.
doi: 10.1038/s41572-019-0106-z 2017;20(2):161-175.
13. Hernandez-Segura A, Nehme J, Demaria M. Hallmarks of doi: 10.1016/j.stem.2017.01.008
cellular senescence. Trends Cell Biol. 2018;28(6):436-453. 25. Sen P, Shah PP, Nativio R, Berger SL. Epigenetic mechanisms
doi: 10.1016/j.tcb.2018.02.001 of longevity and aging. Cell. 2016;166(4):822-839.
14. Liu M, Gomez D. Smooth muscle cell phenotypic diversity. doi: 10.1016/j.cell.2016.07.050
Arterioscler Thromb Vasc Biol. 2019;39(9):1715-1723. 26. Bigarella CL, Liang R, Ghaffari S. Stem cells and the impact
doi: 10.1161/atvbaha.119.312131 of ROS signaling. Development. 2014;141(22):4206-4218.
15. Durham AL, Speer MY, Scatena M, Giachelli CM, doi: 10.1242/dev.107086
Shanahan CM. Role of smooth muscle cells in vascular 27. Lourida KG, Louridas GE. Epigenetic perspective on
calcification: Implications in atherosclerosis and arterial atherosclerotic cardiovascular diseases: The holistic
stiffness. Cardiovasc Res. 2018;114(4):590-600. principle of systems biology and epigenetic reasoning. Glob
doi: 10.1093/cvr/cvy010 Transl Med. 2023;2(4):1868.
16. Cao G, Xuan X, Hu J, Zhang R, Jin H, Dong H. How vascular doi: 10.36922/gtm.1868
smooth muscle cell phenotype switching contributes to 28. Chakravarti D, LaBella KA, DePinho RA. Telomeres: History,
vascular disease. Cell Commun Signal. 2022;20(1):180. health, and hallmarks of aging. Cell. 2021;184(2):306-322.
doi: 10.1186/s12964-022-00993-2 doi: 10.1016/j.cell.2020.12.028
17. Zhang L, Xu Z, Wu Y, Liao J, Zeng F, Shi L. Akt/eNOS 29. Bao H, Cao J, Chen M, et al. Biomarkers of aging. Sci China
and MAPK signaling pathways mediated the phenotypic Life Sci. 2023;66(5):893-1066.
switching of thoracic aorta vascular smooth muscle cells in
aging/hypertensive rats. Physiol Res. 2018;67(4):543-553. doi: 10.1007/s11427-023-2305-0
doi: 10.33549/physiolres.933779 30. O’Callaghan C, Vassilopoulos A. Sirtuins at the crossroads of
stemness, aging, and cancer. Aging Cell. 2017;16(6):1208-1218.
18. Xu M, Wei X, Wang J, et al. The NRF2/ID2 axis in vascular
smooth muscle cells: Novel insights into the interplay doi: 10.1111/acel.12685
between vascular calcification and aging. Aging Dis. 2024. 31. Zhang HN, Dai Y, Zhang CH, et al. Sirtuins family as a target
doi: 10.14336/ad.2024.0075 in endothelial cell dysfunction: Implications for vascular
ageing. Biogerontology. 2020;21(5):495-516.
19. Wang H, Fu H, Zhu R, et al. BRD4 contributes to LPS-
induced macrophage senescence and promotes progression doi: 10.1007/s10522-020-09873-z
of atherosclerosis-associated lipid uptake. Aging (Albany 32. Luna A, Aladjem MI, Kohn KW. SIRT1/PARP1 crosstalk:
NY). 2020;12(10):9240-9259. Connecting DNA damage and metabolism. Genome Integr.
doi: 10.18632/aging.103200 2013;4(1):6.
20. Abe JI, Imanishi M, Li S, et al. An ERK5-NRF2 axis mediates doi: 10.1186/2041-9414-4-6
senescence-associated stemness and atherosclerosis. Circ 33. McReynolds MR, Chellappa K, Baur JA. Age-related NAD
+
Res. 2023;133(1):25-44. decline. Exp Gerontol. 2020;134:110888.
doi: 10.1161/circresaha.122.322017 doi: 10.1016/j.exger.2020.110888
21. Childs BG, Baker DJ, Wijshake T, Conover CA, Campisi J, van 34. Vaidya H, Jeong HS, Keith K, et al. DNA methylation entropy
Deursen JM. Senescent intimal foam cells are deleterious at all as a measure of stem cell replication and aging. Genome Biol.
stages of atherosclerosis. Science. 2016;354(6311):472-477. 2023;24(1):27.
doi: 10.1126/science.aaf6659 doi: 10.1186/s13059-023-02866-4
22. Wang L, Hong W, Zhu H, et al. Macrophage senescence in 35. Bi S, Jiang X, Ji Q, et al. The sirtuin-associated human
health and diseases. Acta Pharm Sin B. 2024;14(4):1508-1524.
senescence program converges on the activation of placenta-
doi: 10.1016/j.apsb.2024.01.008 specific gene PAPPA. Dev Cell. 2024;59(8):991-1009.e12.
Volume 3 Issue 4 (2024) 11 doi: 10.36922/gtm.4619

