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Global Translational Medicine Blood parameters for SCLC and AC relapse prognosis

Table 1. Characteristics of patients with SCLC Table 2. Characteristics of patients with AC
Parameter Retrospective Study P‑value Parameter Retrospective Study P‑value
group (%) group (%) group (%) group (%)
Number of patients, total 416 73 Number of patients, total 451 77
Age, years (M±σ) 58±29 59±27 0.379 Age, years (M ± σ) 59±26 58±28 0.258
<40 17 (4.1) 2 (2.7) <40 14 (3.1) 3 (3.9)
41 – 50 72 (17.3) 13 (17.8) 41 – 50 75 (16.6) 13 (16.9)
51 – 60 197 (47.4) 33 (45.2) 51 – 60 201 (44.6) 38 (49.4)
61 – 70 98 (23.6) 20 (27.64) 61 – 70 107 (23.7) 20 (26.0)
>70 32 (7.7) 5 (6.8) >70 54 (12.0) 3 (3.9)
Gender 0.435 Gender 0.315
Male 297 (71.4) 56 (76.7) Male 329 (72.9) 58 (75.3)
Female 119 (28.6) 17 (23.3) Female 122 (27.1) 19 (24.7)
Smoking status, male 0.286 Smoking status, male 0.193
Former 18 (6.1) 7 (12.5) Former 21 (6.4) 7 (12.5)
Current 267 (89.9) 46 (82.1) Current 285 (86.6) 48 (85.7)
Never 12 (4.0) 3 (5.4) Never 23 (7.0) 3 (5.4)
Smoking status, female 0.315 Smoking status, female 0.143
Former 20 (16.8) 2 (11.8) Former 27 (22.1) 5 (26.3)
Current 93 (78.2) 14 (82.4) Current 86 (70.5) 12 (63.2)
Never 6 (5.0) 1 (5.9) Never 9 (7.4) 2 (10.5)
Stage III (based on 8 edition of TNM staging of lung 0.421 Stage III (based on 8 edition of TNM staging of lung 0.329
th
th
cancer) cancer)
T1N2M0 46 (11.1) 7 (9.6) T1N2M0 50 (11.1) 7 (9.1)
T2N2M0 69 (16.6) 15 (20.5) T2N2M0 72 (16.0) 16 (20.8)
T3N1M0 66 (15.9) 10 (13.7) T3N1M0 72 (16.0) 9 (11.7)
T4N0M0 48 (11.5) 9 (12.3) T4N0M0 53 (11.8) 10 (13.0)
T4N1M0 50 (12.0) 9 (12.3) T4N1M0 55 (12.2) 11 (14.3)
T3N2M0 76 (18.3) 12 (16.4) T3N2M0 84 (18.6) 13 (16.9)
T4N2M0 61 (14.7) 11 (15.1) T4N2M0 65 (14.4) 11 (14.3)
Degree of tumor differentiation 0.127 Degree of tumor differentiation 0.724
G I 150 (36.1) 23 (31.5) G I 168 (37.3) 25 (32.5)
G II 166 (39.9) 37 (50.71) G II 184 (40.8) 39 (50.6)
G III 100 (24.0) 13 (17.8) G III 99 (21.9) 13 (16.9)
Localization 0.519 Localization 0.357
Right lung 215 (51.7) 41 (56.2) Right lung 249 (55.2) 40 (51.9)
Left lung 201 (48.3) 32 (43.8) Left lung 201 (44.8) 37 (48.1)
Abbreviation: SCLC: Squamous cell lung cancer. Abbreviation: AC: Adenocarcinoma.

were determined using a biochemical analyzer AU680 The concentrations of CYFRA 21-1 and SCC were
(Beckman Coulter, USA) with original reagent kits. The SII determined using an automatic Cobas e411 analyzer
was calculated using the equation P × N/L, where P, N, and (Rosche Diagnostics GmbH, Germany), based on the
L are platelets, neutrophils, and lymphocytes, respectively. principle of electrochemiluminescence. 11
The IPI was calculated as ([CRP] × N)/(L × [albumin]), The concentrations of CXCL5, CXCL8, TPA, HIF -1α,
while the systemic inflammatory response index (SIRI) TuM2 PK, and hyaluronic acid were measured on a Brio
was calculated using the equation N × M/L, where M automatic ELISA analyzer (Seac, Italy) with ELISA kits
represents monocytes. (FineTest, China). 12

Volume 3 Issue 4 (2024) 4 doi: 10.36922/gtm.4865