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Global Translational Medicine Connective tissue harvest techniques

analyses, case reports, and expert opinion from key figures Ethics approval and consent to participate
in the field of periodontology.
Not applicable.
5. Conclusion Consent for publication

It is striking that significant gaps in knowledge still exist
regarding the SCTG – a well-established and reliable Not applicable.
method for gingival/mucosal augmentation, and the Availability of data
recognized gold standard for root coverage. Periodontists
have yet to fully understand the differences among SCTG Not applicable.
types at the clinical, ultrastructural, and molecular levels. References
However, the available evidence suggests that the SIT is
generally preferred, as it may optimize both clinical and 1. Chambrone L, Ortega MA, Sukekava F, et al. Root coverage
patient-oriented outcomes in most situations. The attributes procedures for treating single and multiple recession‐
of alternative graft types, such as tSCTGs and DGGs, may type defects: An updated Cochrane systematic review.
offer significant advantages in specific clinical scenarios. J Periodontol. 2019;90(12):1399-1422.
Initial studies comparing gene expression and protein doi: 10.1002/JPER.19-0079
distribution among various graft types are consistent 2. Chambrone L, Tatakis DN. Periodontal soft tissue
with observed differences in clinical performance. Recent root coverage procedures: A systematic review from
advances in our understanding of human palatal anatomy the AAP regeneration workshop. J Periodontol.
have substantially expanded the safety zone for palatal 2015;86(Suppl):S8-S51.
SCTG harvesting, allowing a broader mesiodistal span to doi: 10.1902/jop.2015.130674.
be addressed in a single procedure. tSCTGs, DGGs, and
SCTGs obtained from deep palatal tissue are structurally 3. Cairo F, Nieri M, Pagliaro U. Efficacy of periodontal plastic
distinct, exhibit unique clinical limitations, and have surgery procedures in the treatment of localized facial
potential to produce different treatment outcomes. Future gingival recessions. A systematic review. J Clin Periodontol.
2014;41(Suppl 15):S44-S62.
studies, particularly those utilizing modern laboratory
techniques, will help elucidate the biological basis for these doi: 10.1111/jcpe.12182
graft-related differences. In addition, further controlled 4. Wessel JR, Tatakis, DN. Patient outcomes following
clinical research is needed to validate indications for each subepithelial connective tissue graft and free gingival graft
graft type. procedures. J Periodontol. 2008;79(3):425-430.
Acknowledgments doi: 10.1902/jop.2008.070325
5. Berridge JP, Johnson TM, Cheng AW, Swenson DT, Miller
None. PD Jr. Focus on epithelialized palatal grafts. Part 3: Methods
to enhance patient comfort at palatal donor sites. Clin Adv
Funding Periodontics. 2019;9(4):177-184.
The research was entirely funded by the Defense Health doi: 10.1002/cap.10066
Agency (United States), with no extramural funding 6. Tavelli L, Barootchi S, Stefanini M, Zucchelli G, Giannobile
provided to the authors.
WV, Wang HL. Wound healing dynamics, morbidity, and
Conflict of interest complications of palatal soft-tissue harvesting. Periodontol
2000. 2023;92(1):90-119.
The authors declare that they have no competing interests.
doi: 10.1111/prd.12466
Author contributions 7. Tavelli L, Barootchi S, Di Gianfilippo R, et al. Patient
experience of autogenous soft tissue grafting has an
Conceptualization: Thomas M. Johnson implication for future treatment: A 10- to 15-year cross-
Methodology: Han S. Kim, Denise M. Cacho, Alan R. sectional study. J Periodontol. 2021;92(5):637-647.
George, Joseph R. Retrum, Carsen R. McDaniel
Writing – original draft: Han S. Kim, Denise M. Cacho, Alan doi: 10.1002/JPER.20-0350
R. George, Joseph R. Retrum, Carsen R. McDaniel, 8. Harris RJ. The connective tissue and partial thickness
Thomas M. Johnson double pedicle graft: A predictable method of obtaining root
Writing – review & editing: Brian W. Stancoven, Kimberly coverage. J Periodontol. 1992;63(5):477-486.
Ann Inouye, Adam R. Lincicum doi: 10.1902/jop.1992.63.5.477

Volume 4 Issue 1 (2025) 44 doi: 10.36922/gtm.4860