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Global Translational Medicine Precision medicine via personalized nutrition

ethical considerations surrounding genomic data sharing, nutritional tracking, ultimately leading to better health
the high variability of multiomics data in biological outcomes. The role of nutrients in regulating gene activity,
samples, and the shortage of skilled professionals in both directly and indirectly, opens up new pathways for
big data generation, analysis, and management must be PN in the prevention and treatment of chronic health
addressed to ensure the continued advancement of PN. conditions.

With advancements in omics techniques, the concept of We are entering an era defined by PN, PF, and
food has evolved beyond being merely a source of energy, molecular food design, which is reshaping our approach to
macronutrients, and micronutrients. It is now recognized health and wellness. This shift calls for the development of
as a key determinant of overall health and well-being. global scientific, clinical, social, and educational initiatives
The intricate relationship between micronutrients focused on PPM to foster this emerging branch. As we look
and gene expression plays a crucial role in various to the future, digital advancements will propel PN-based
pathophysiological processes and offers valuable insights therapies to new levels of accessibility, personalization, and
into disease prevention. Understanding these interactions precision. Technologies such as ML and big data analytics
can help delay the onset of chronic disorders, paving the are set to revolutionize the medical nutrition sector, while
way for more targeted and effective nutritional strategies. their integration into wearable devices, mobile platforms,
and smart devices will further enhance accessibility for
Emerging technologies in omics-guided applications, patients.
such as nutrigenomics and deep phenotyping, have
enabled the collection of extensive data on genetic In the coming years, the integration of PF, PN,
markers, clinical indicators, precise body composition systems biology, and general pathology will yield valuable
metrics, and dietary consumption. The complex interplay insights into areas such as host–microbiome interactions,
between genetics, dietary habits, and lifestyle influences nutritional immunology, pathogen resistance in food
an individual’s risk of developing CVD. For instance, in microorganisms, and farm–animal production. This
cases of hypercholesterolemia, a key challenge lies in the unified approach will also help us better understand post-
misalignment between genes regulating lipid metabolism harvest phenomena by linking genetic and environmental
and the modern diet, compounded by various lifestyle responses, ultimately identifying key bionetworks that
factors. The primary challenge in both PN and PPM influence health outcomes.
is effectively translating these insights into clinically
actionable and relevant recommendations for improved Acknowledgments
health outcomes. We would like to especially thank Joaquín Parodi Román
A deeper understanding of nutrient–gene–metabolite and Carmen Escobedo Monge for their technical support
pathways will enable a more integrated approach to in the preparation and presentation of this article.
cellular studies at different levels. In this context, the
interactions between gut microbiota and food should Funding
be thoroughly assessed. PN should focus on selecting None.
the most appropriate foods for each individual, based
on their effects on gene expression and gut microbiota Conflict of interest
composition. In addition to their primary function as an The authors declare they have no competing interests.
energy source, foods will increasingly be chosen for their
bioactive components. Author contributions
PN has the potential to revolutionize health-care by Conceptualization: Sergey Suchkov, Marlene Escobedo-
offering tailored meal plans and progress tracking, designed Monge, Veronika Polyakova
to align with an individual’s unique characteristics and Visualization: Veronika Polyakova, Olga Goryacheva,
health goals. To fully grasp the integrated relationship Elena Antonova, Robert H. Lustig, Sofia Blokh,
between PN and health, it is essential to understand the Natalya Andronova, Marina Borisovna Moyseyak,
underlying mechanisms governing systemic flexibility. Timur Vlasov, Aleksandr Tuykavin
Many of these mechanisms are influenced by PN, directly Writing–original draft: Sergey Suchkov, Veronika
impacting health outcomes and overall well-being. Polyakova, Marlene Escobedo-Monge
Following PN guidelines can significantly enhance Writing–review & editing: Sergey Suchkov, Marlene
disease management by focusing on diet-based Escobedo- Monge, Veronika Polyakova, Natalya
biochemistry, insulin regulation, nutrient absorption, and Andronova

Volume 4 Issue 3 (2025) 77 doi: 10.36922/GTM025080017