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Global Translational Medicine Precision medicine via personalized nutrition

science. By generating high-throughput molecular data, information—is driving the development of innovative
omics enables a deeper understanding of the complexities health products and services tailored to individual needs.
of nutrition, fundamentally reshaping the field. By leveraging online tools such as questionnaires, along
From both translational and clinical perspectives, with advanced data sources such as wearable devices, DNA
staying informed about these emerging directions in analysis, blood biomarkers, and microbiome profiling,
nutritional science is essential for advancing health and PN-driven approaches are advancing. These strategies
disease management. By collecting individual data at enable the creation of products that are more precisely
the genetic, phenotypic, medical, and nutritional levels formulated to align with an individual’s lifestyle, genomic
and using these data to provide personalized dietary predisposition, and metabolic requirements, surpassing
recommendations, PN aims to maintain or improve health. anything currently available.
Disease prevention and the treatment of existing conditions 4.1. Food products enriched with autoprobiotics
further enhance its effectiveness. Enhancing human health
through PN has become a subject of significant interest. It has been shown for the first time that exposure to
In this sense, multiomics can be leveraged to analyze the probiotic preparations under conditions simulating space
microbiota, metagenome, proteome, transcriptome, and flight factors inherent in interplanetary expeditions (e.g.,
metabolome, offering a detailed understanding of an hypomagnetic environment, altered radiation background)
individual’s physiological state. As PN gains momentum, does not lead to changes in their quality. Therefore,
advancements in multiomics technologies are expected to probiotics may be used in expeditions to the Moon,
shape future practice by facilitating the identification of following recommendations established under terrestrial
objective nutritional biomarkers that link dietary intake conditions. The use of food products enriched with
with health status. 86 autoprobiotics exerts an effective stabilizing effect on the
human intestinal microbiota in experiments simulating the
The progress of PN will be driven by several key impact of space flight factors. Thus, food products enriched
factors linked to the growing body of scientific evidence. with autoprobiotics are considered promising for medical
First, establishing a robust theoretical framework that support during long-term, including interplanetary
identifies the most relevant individual characteristics space flights. This work experimentally substantiates the
for PN is essential. Second, well-structured intervention development of food products incorporating autologous
studies must provide evidence of PN’s effectiveness microorganisms, representatives of the protective
and cost-efficiency. Finally, implementing a regulatory intestinal microflora. The impact of a combination of
framework will be crucial for safeguarding public interest altered environmental factors (e.g., radiation exposure,
and instilling confidence among health-care professionals
and policymakers. Achieving these goals will require a freezing, hypomagnetic environment) does not adversely
significant expansion of scientific research in the field. 95 affect the probiotic properties of individual cultures or
their associations. These findings suggest that technologies
In this new dietary era, marked by a societal shift from for enriching food products with autoprobiotics may be
merely consuming what is available to making healthy applicable to future programs for deep space exploration. 101
and conscious decisions, rethinking and refining dietary
habits has become increasingly important as we move 5. Conclusion
toward PN tailored to individual needs. In addition, by Human PN is a specialized branch of PPM that focuses on
leveraging advanced analytics, PN can deliver personalized the biochemical connections between food and the human
dietary advice that accounts for each individual’s unique body. The shift from a healthy state to disease is influenced
characteristics, preferences, and health goals. This by variations in gene and protein expression, leading to the
approach offers the potential to enhance overall health, emergence of “omics sciences” as a critical field of study.
support chronic disease management, and maximize
athletic performance. As technology and research continue As discussed in the previous sections, significant
to advance, PN provides a new avenue for improving progress has been made in PN due to a growing body of
individual health and well-being. research supporting its effectiveness. Nonetheless, a deeper
understanding of the complex interactions between genes
The integration of PN with PF is evolving beyond a mere
trend, driven by a new generation of consumers seeking and diet remains essential, especially as the development of
novel food products further increases complexity.
clarity amid the confusion of mass-marketed, one-size-
fits-all nutritional products. The fusion of technological The successful implementation of PN models in real-
advancements and growing consumer awareness of world settings is crucial for transforming theoretical
nutrition and wellness—along with greater access to relevant concepts into practical applications. Challenges such as

Volume 4 Issue 3 (2025) 76 doi: 10.36922/GTM025080017