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International Journal of AI for
            Materials and Design                                           ML-driven optimization in additive manufacturing


            demonstrated a  99.03% F1-score,  highlighting the  high   top-down setup places the laser or projector above the resin,
            accuracy of the proposed detection method (Figure 3B).   lowering the platform with each layer, which can disturb
            Another study leveraged ML to predict the printability of   the resin surface level and expose the newly formed layer to
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            bioink formulations.  A total of 210 bioink compositions   ambient oxygen, thereby inhibiting photopolymerization.
            were experimentally constructed from 16 biomaterials,   It also tends to require larger vats and more resin volume.
            and decision trees, RF, and ANN were compared. Notably,   By contrast, bottom-up printing positions the light source
            the RF model achieved the highest precision (90.6%)   below the vat and raises the platform upward. While this
            and accuracy (88.1%), thus providing reliable bioink   reduces  some  top-down  constraints,  separating  each
            recommendations, while ANN offered better recall (87.3%)   cured layer from the transparent vat window can induce
            and demonstrated superior extrapolation capability. These   mechanical stress. Several ML-driven approaches have
            findings illustrate how data-driven methods can overcome   been proposed to optimize bottom-up printing. 53,99,100
            the limitations of purely experimental approaches, enabling   One group developed a real-time monitoring system to
            rapid identification of optimal formulations.      detect part detachment during the upward movement of
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              In vat photopolymerization, process parameters–such   the build platform in DLP.  Using strain gauges to track
            as light intensity, exposure time, print speed, and build   platform deformation and a photodetector to measure
            orientation–must be considered alongside resin properties   UV exposure; they applied an RF classifier along with an
            (viscosity, photoinitiator concentration, and reactivity). 84,87-90    exponentially weighted moving average p-control chart to
            When printing  solid-particle–filled resins in  DLP, light   detect part detachment in real time and halt the process
            scattering may occur as particles interact with the curing   automatically. The system achieved an F1-score of 99.03%
            beam. 91-93  A similar phenomenon can emerge when cells are   and demonstrated robust process stability by stopping
            included in a hydrogel-based bioink due to refractive index   printing after repeated detections. Another study proposed
            differences between cells and the surrounding gel. 67,91,92    an ML-driven predictive model to optimize idle times
            Scattering diverts light away from the intended target   during the bottom-up approach, where the platform was
            region, compromising pattern fidelity. Recent research   raised, fresh resin flowed in, and the platform descended
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            used a deep learning-based correction method to mitigate   again.  Introducing the concept of a prediction feature
            cell-induced light scattering and enhance print quality in   region allowed them to estimate wait time effectively
            DLP-based bioprinting.  A master-slave neural network   without resorting to complex fluid simulations. A multi-
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            based on U-Net was employed to automatically generate   layer perceptron model was trained to identify geometry-
            optimized correction masks that suppress the scattering   specific idle times, yielding a 47% reduction in average
            effect. This approach can significantly reduce iterative trial-  waiting time and a 25% overall reduction in total print
            and-error. Another study addressed grayscale DLP printing   time compared with conventional methods. Similarly, for
            optimization by building a recurrent neural network (RNN)   bottom-up SLA, a deep learning model has been employed
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            with LSTM layers to learn the relationship between per-  to predict layer-wise stress distributions.  Training
            pixel grayscale values and the final deformed structure.    datasets built from FEA simulations fed into a basic CNN
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            Coupling this with finite element modeling (FEM) enabled   and a 2-Stream CNN architecture achieved up to a 55%
            faster and more accurate deformation prediction, while   reduction in prediction error compared to a conventional
            an evolutionary algorithm (EA) optimized grayscale   neural network (NN) model with high accuracy even in
            distribution to achieve target deformation patterns. The   non-uniform geometries.
            proposed ML–EA hybrid approach significantly reduced   ML has also been leveraged for high-precision vat
            computational  time  compared  with  conventional  FEM-  photopolymerization (Figure  3C). In one DLP study, an
            centric optimization, maintaining comparable precision.   RF model was trained to learn the relationships between
            In a separate effort to improve geometric fidelity, boundary   UV exposure time, light intensity, layer thickness, and
            distortion in vat photopolymerization was mitigated using   final print error. This approach maintained an average
            an  ML-driven  model  that  predicts  and  compensates  for   printing error below 2.3 µm.  Moreover, it demonstrated
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            boundary shifts during layer projection.  More recently,   a  minimum  feature  size  of  ~20  µm  in  complex  triply
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            ML-guided temperature prediction models have been   periodic minimal surface structures, highlighting the
            coupled with numerical simulation to develop optimized   model’s capacity for generalization to intricate geometries.
            control schemes for DLP printing, improving thermal   In addition, ML-based surrogate modeling has been
            uniformity and curing accuracy. 95                 applied in projection two-photon lithography to optimize

              In SLA and DLP, the printing apparatus can be arranged   polymerization dynamics and improve printability, further
            in either top-down or bottom-up configurations. 96-98  The   enhancing precision in microscale fabrication. 102


            Volume 2 Issue 2 (2025)                         36                        doi: 10.36922/IJAMD025130010
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