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International Journal of Bioprinting In situ bioprinting for cartilage repair

good as that in the in situ bioprinting group. Nevertheless, Ethics approval and consent to participate
due to the limited research on the in situ bioprinting for All the animal experiment protocols were approved by
cartilage repair, the mechanisms of in situ bioprinting in the Ethical Committee of Laboratory Animals of Peking
repairing cartilage defects remain to be delineated, and
thus, more investigations are warranted. University Third Medical School and were conducted
24
in adherence with the Guide for the Care and Use of
5. Conclusion Laboratory Animals (A2022008).
In this paper, in situ repair of cartilage defects was achieved Consent for publication
using a parallel manipulator. Accurate control of the filament
diameter during printing can be achieved through process Not applicable.
optimization. The bimodal method was conducted for the
defect segmentation, and a self-compiled code was developed Availability of data
to perform in situ reconstruction of the defects. The in vitro Data used in this work is available from the corresponding
and in vivo experiment results showed that in situ bioprinting author upon reasonable request.
for the purposes of repairing cartilage defects can be realized
with in situ 3D printing technology, which shows promising References
potential in clinical applications. In practice, there may be
certain differences in the z-axis of cartilage defects. In this 1. Li M, Yin H, Yan Z, et al. The immune microenvironment in
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in future work to further optimize the 3D information. technical and regulatory challenges on tissue-engineered
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the Key-Area Research and Development Program of 4. Chen YR, Yan X, Yuan FZ, et al. Kartogenin-conjugated
Dongguan (20221200300182), the Key Clinical Projects double-network hydrogel combined with stem cell
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the Shenzhen Science and Technology Planning Project (Weinh). 2022;9(35):e2105571.
(JSGG20210802153809029), the National Natural Science doi: 10.1002/advs.202105571
Foundation of China (82102565, 82002298, 51920105006), 5. Zhang Y, Liu X, Zeng L, et al. Polymer fiber scaffolds for
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The authors declare that they have no known competing
financial interests or personal relationships that could have 6. Browe D, Burdis R, Diaz-Payno PJ, et al. Promoting endogenous
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Author contributions
7. Li X, Zheng F, Wang X, et al. Biomaterial inks for extrusion-
Conceptualization: Jia-Kuo Yu, Chang-Hui Song based 3D bioprinting: Property, classification, modification,
Formal analysis: Hao-Yang Lei, You-Rong Chen, Zi-Bin and selection. Int J Bioprint. 2022;9(2).
Liu, Yi-Nong Li doi: 10.18063/ijb.v9i2.649
Investigation: Hao-Yang Lei, You-Rong Chen, Bing-Bing Xu 8. Sadeghianmaryan A, Naghieh S, Yazdanpanah Z, et al.
Methodology: Hao-Yang Lei, You-Rong Chen, Bing-Bing Xu Fabrication of chitosan/alginate/hydroxyapatite hybrid
Project administration: Jia-Kuo Yu scaffolds using 3D printing and impregnating techniques
Writing – original draft: Hao-Yang Lei for potential cartilage regeneration. Int J Biol Macromol.
Writing – review & editing: Hao-Yang Lei, You-Rong Chen, 2022;204:62-75.
Bing-Bing Xu doi: 10.1016/j.ijbiomac.2022.01.201

Volume 10 Issue 1 (2024) 393 https://doi.org/10.36922/ijb.1437