Page 173 - IJB-10-2

International

Journal of Bioprinting

REVIEW ARTICLE
Potential of bioprinted intestine-on-chip

models in advancing understanding of human
coronavirus infections and drug screening

Min-Hyeok Kim , Jeeyeon Lee , Chwee Teck Lim 2,3,4 , and Sungsu Park *
2
1,5
1
1 School of Mechanical Engineering, Sungkyunkwan University (SKKU), Suwon, Republic of Korea
2 Institute for Health Innovation and Technology (iHealthtech), National University of Singapore,
Singapore
3 Department of Biomedical Engineering, National University of Singapore, Singapore
4 Mechanobiology Institute, National University of Singapore, Singapore
5 Department of Biophysics, Institute of Quantum Biophysics (IQB), Sungkyunkwan University
(SKKU), Suwon, Republic of Korea
(This article belongs to the Special Issue: Role of 3D Printing Processes in Medicine)

Abstract

Human coronaviruses, including severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2), contribute to both respiratory and gastrointestinal symptoms,
necessitating a comprehensive approach to studying viral pathogenesis. In this
context, bioprinted intestine-on-chip models offer a cutting-edge technology for
closely replicating the tissue architecture and microenvironment of the human
intestine, providing valuable insights into viral dynamics and host responses.
Integration of intestinal organoids with organoid-on-chip technology enhances
*Corresponding author: the accuracy of modeling SARS-CoV-2 infection by means of improving cellular
Sungsu Park differentiation and virus-binding receptor expression. Furthermore, bioprinting
(nanopark@skku.edu)
technology allows for automated fabrication, enabling high-throughput drug
Citation: Kim M-H, Lee J, Lim screening on the intestine-on-chip platform. These advancements in bioprinted
CT, Park S. Potential of bioprinted intestine-on-chip models hold immense promise for advancing our understanding
intestine-on-chip models in
advancing understanding of of coronavirus infection in the gut and accelerating drug development, ultimately
human coronavirus infections contributing to improved patient outcomes and public health measures.
and drug screening. Int J Bioprint.
2024;10(2):1704.
doi: 10.36922/ijb.1704 Keywords: Intestine; Bioprinting; Organ-on-chip; Coronavirus; Drug screening
Received: August 29, 2023
Accepted: November 9, 2023
Published Online: January 23, 2024
Copyright: © 2024 Author(s). 1. Introduction
This is an Open Access article
distributed under the terms of the Human coronaviruses, including severe acute respiratory syndrome coronavirus 2
Creative Commons Attribution (SARS-CoV-2), lead to a spectrum of respiratory illnesses, ranging from mild cold-like
License, permitting distribution,
and reproduction in any medium, symptoms to severe diseases like severe acute respiratory syndrome (SARS), Middle
provided the original work is East respiratory syndrome (MERS), and coronavirus disease 2019 (COVID-19).
properly cited. Besides respiratory manifestations, these viruses can also induce gastrointestinal
Publisher’s Note: AccScience symptoms, such as diarrhea, nausea, and vomiting (Figure 1). Understanding the
Publishing remains neutral with mechanisms and consequences of gut infection holds direct clinical implications,
regard to jurisdictional claims in
published maps and institutional offering valuable insights for targeted interventions to alleviate gastrointestinal distress,
affiliations. curb transmission through fecal shedding, and address potential long-term gut-related

Volume 10 Issue 2 (2024) 165 doi: 10.36922/ijb.1704