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International Journal of Bioprinting hNVU chip for brain modeling and drug screening
Figure 6. Evaluation of the therapeutic effects of the hNVU chip for screening drugs against pediatric brain tumors. (A) Schematic representation of the
hNVU model. (B) Live and dead results of cells in the brain region under the action of chemotherapeutic drugs. (C, D) Evaluation of the penetration
of 5-FU (50 μg/mL) and vorinostat (0.24 μg/mL) at blood concentrations across the BBB. (E) Drug genotoxicity and expression changes of therapeutic
target genes. (F) Metabolic flux analysis of brain region cells reveals the therapeutic effects of 5-FU and vorinostat. C13-labeled glucose was provided as
the glucose source in the system. n = 3, independent experiments. Data are presented as the mean ± S.D. Significant differences between the groups were
determined by t-test.
Volume 10 Issue 3 (2024) 353 doi: 10.36922/ijb.1684
