Page 85 - IJB-10-3

International Journal of Bioprinting 3D printing technology in neurotrauma

Qian et al. fabricated a PCL conduit loading with PDA- Conflict of interest
coated gold nanoparticles by an extrusion printing The authors declare no conflicts of interest.
process. They found that the scaffold could provide a
183
favorable microenvironment for BMSCs and Schwann Author contributions
cells in vitro. After loading with BMSCs and Schwann
cells, they demonstrated that the conduit could promote Conceptualization: Yu Hu
axonal regeneration and remyelination in a sciatic nerve Funding acquisition: Yu Hu, Wenbi Wu
defect model. 183 Supervision: Maling Gou
Visualization: Wenbo He
4. Conclusion and future outlook Writing – original draft: Wenbo He, Chongxi Xu, Wenbi
Wu, Yuchen Chen, Jingxuan Hou, Zhouhaoran Chen
The emerging 3D printing technology has the characteristics Writing – review & editing: Jianguo Xu, Yu Hu, Maling Gou
of design flexibility, personalized customization, and
controllable manufacturing accuracy. Taking advantage of Ethics approval and consent to participate
the advanced technology, we could fabricate functionalized
neural constructs based on multiple strategies, such as Not applicable.
biomaterials, physical stimulation, bioactive substances,
cell transplantation, and their combination, for efficient Consent for publication
neurotrauma treatment. At present, although significant Not applicable.
progresses have been achieved in the application of 3D
printing in neurotrauma treatment, challenges still remain. Availability of data
First, in order to accurately manufacture constructs with
customized functions, the 3D printing system needs to Not applicable.
be optimized, especially in terms of accuracy and speed.
Second, the biomaterials available for printing are limited. References
The properties of printable biomaterials for neurotrauma,
such as degradability, biocompatibility, and mechanical 1. Peppiatt CM, Howarth C, Mobbs P, Attwell D. Bidirectional
control of CNS capillary diameter by pericytes. Nature.
properties, could be further improved. Choosing a 2006;443(7112):700-704.
combination of various biomaterials may be an alternative doi: 10.1038/nature05193
option. Third, for the purpose of clinically translating
3D-printed devices into applications for neurotrauma 2. Bican O, Minagar A, Pruitt AA. The spinal cord: a review of
treatment, it is still a huge challenge to fabricate constructs functional neuroanatomy. Neurol Clin. 2013;31(1):1-18.
doi: 10.1016/j.ncl.2012.09.009
suitable for humans and test them on large animals or even
conduct clinical trials. More importantly, exploring and 3. Catala M, Kubis N. Gross anatomy and development of
elucidating the repair mechanism of a damaged nervous the peripheral nervous system. Handb Clin Neurol. 2013;
system is of great significance and can provide direction 115:29-41.
for the design of new 3D-printed products. Finally, doi: 10.1016/b978-0-444-52902-2.00003-5
3D-printed constructs with synergetic combination of 4. Suter T, Jaworski A. Cell migration and axon guidance at
multiple neurotrauma treatment strategies to achieve the border between central and peripheral nervous system.
multi-angle and sequential treatment are expected to lead Science (New York, NY). 2019;365(6456).
to breakthroughs in the future. doi: 10.1126/science.aaw8231
5. Lozano JCM, Gomez RM, Sanabria AGZ, Jubiz G, Valderrama
Acknowledgments S. Genetic aspects of glial cells regarding neurodegenerative
diseases. Curr Pharm Des. 2018;24(15):1727-1735.
None. doi: 10.2174/1381612823666170828134055

Funding 6. Shafiee A, Ahmadi H, Taheri B, et al. Appropriate scaffold
selection for CNS tissue engineering. Avicenna J Med
This work was supported by National Natural Science Biotechnol. 2020;12(4):203-220.
Foundation of China (grant number: 82001320), Key R&D 7. Alilain WJ, Horn KP, Hu H, Dick TE, Silver J. Functional
projects in Sichuan Province (2022YFS0319), and Post- regeneration of respiratory pathways after spinal cord injury.
Doctor Research Project, West China Hospital, Sichuan Nature. 2011;475(7355):196-200.
University (No. 2023HXBH081). doi: 10.1038/nature10199

Volume 10 Issue 3 (2024) 77 doi: 10.36922/ijb.2311