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Choudhury D, et al.

Figure 6. Large Bioprinters: (a) BIOASSEMBLYBOT courtesy of Advanced Solutions Life Sciences, Kentucky, US); (B) REGENOVA
®
(courtesy of Cyfuse Biomedical K.K., Tokyo, Japan); (c) NGB 17.03 (courtesy of Poietis, France); (D) 3Dn 300 TE Series (courtesy of
nScrypt, Orlando, US) (e) Bio-Architect (courtesy of Regenovo Biotechnology Co.Ltd., Hnagzhou, China); (F) BioFactory™ (courtesy
®
of RegenHU, Fribourg, Switzerland); (G) ALPHA-CPT1 (courtesy of SunP Biotech International, NJ, US).
Bio3D Technologies launched its first modular extrusion bioprinter with dual print heads and a UV
bioprinter in August 2014. The key highlights of their LED system. In 2017, CELLINK launched BIO X
technology include an anti-vibration levitating platform, (Figure 5G). Some of the key highlights of BIO X
multiple interchangeable printing heads, nozzle-to- include exchangeable print heads, UV curing tool
platform auto-alignment and remote viewing and head, cool pneumatic head, HD camera tool head and
control. One of the models, Bio3D Explorer, stands out printbed temperature control (4–60 °C). Bio X is a fully
as being the first foldable bioprinter designed for easy standalone product which offers two different ways of
[76]
transportation . ensuring clean printing chambers: (a) The HEPA H14
BIOLIFE4D is an upcoming biotech firm founded in filter positive air system which retains germs and other
2015, with headquarters at Illinois (USA). The company dust particles and (b) UVC germicidal lamps to sterilize
aspires to 3D bioprint a fully functional, patient-specific the printing chamber.
heart for safe and affordable organ transplantation [77] . Cyfuse Biomedical K. K developed their bioprinter
®
They are a strong team of business leaders and Regenova (Figure 6B) in partnership with Kanazawa-
biomedical researchers, currently financed through based Japanese medical-device manufacturer, Shibuya
[78]
equity crowdfunding in their scientific endeavour . The Kogyo Co. Ltd. In 2016, the company also collaborated
BIOLIFE4D technology intends to use adult induced with San Diego-based Cell Applications Inc. allowing
pluripotent stem cells (iPSCs) for 3D bioprinting a them to create scaffold-free, 3D-engineered tissues using
human heart, after conducting a thorough MRI scan to the novel Kenzan bioprinting method [81] . Regenova
obtain the specific dimensions for its construction. applies a novel robotic approach that enables the
CELLINK markets both bioprinters and a wide- fabrication of three-dimensional cellular structures by
range of bioinks [79,80] . In fact, CELLINK was the first placing cellular spheroids in a temporary array of fine
to commercialize bioinks for bioprinting applications. needles; a methodology has been termed as “Kenzan”.
INKREDIBLE (Figure 4D) is a pneumatic-based The company in collaboration with Cell Applications

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