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International Journal of Bioprinting 3D cartilage induction and monitoring

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Proyecto (P21_00182), the Consejería de Transformación nucleus pulposus : a comparative review of cartilage-like
Económica, Industria, Conocimiento y Universidades, tissues in anatomy, development and function. Cell Tissue
Junta de Andalucía, Modeling Nature (MNat; project no.: Res. 2017;370(1):53-70.
QUAL21-11), the Instituto de Salud Carlos III (ERDF funds; doi: 10.1007/s00441-017-2613-0
project nos.: DTS19/00145 and DTS21/00098), the Ministry 5. Houard X, Goldring MB, Berenbaum F. Homeostatic
of Education (grant nos.: EQC2018-004508-P, DPI2017- mechanisms in articular cartilage and role of inflammation
83859-R, and UNGR15-CE-3664) and Junta de Andalucía in osteoarthritis. Curr Rheumatol Rep. 2013;15(11):375.
(grant nos.: B-TEP-026-UGR18, IE2017-5537, P18- doi: 10.1007/s11926-013-0375-6
RT-1653). G.J. received the postdoctoral fellowship from 6. Heinegård D, Saxne T. The role of the cartilage matrix in
Plan Andaluz de Investigación, Desarrollo e Innovación osteoarthritis. Nat Rev Rheumatol. 2011;7(1):50-56.
(PAIDI 2020—FEDER funds—Ref: DOC_01574). doi: 10.1038/nrrheum.2010.198
7. Martínez R, Martínez C, Calvo R, Figueroa D. Osteoartritis
Conflict of interest (artrosis) de rodilla. Chilean J Orthop Traumatol.
The authors declare no conflicts of interest. 2015;56(3):45-51.
doi: 10.1016/j.rchot.2015.10.005
Author contributions 8. Makris EA, Gomoll AH, Malizos KN, Hu JC, Athanasiou
Conceptualization: Daniel Martínez-Moreno, Guillermo KA. Repair and tissue engineering techniques for articular
cartilage. Nat Rev Rheumatol. 2015;11(1):21-34.
Rus, Juan Antonio Marchal
Investigation: Daniel Martínez-Moreno, Antonio Callejas doi: 10.1038/nrrheum.2014.157
Formal analysis: Daniel Martínez-Moreno, Antonio Callejas 9. European Medicines Agency. Spherox. Spherox - EMEA/
Writing - original draft: Daniel Martínez-Moreno, H/C/002736 - II/0020; 2021. Accessed July 28, 2022.
Antonio Callejas https://www.ema.europa.eu/en/medicines/human/EPAR/
Writing - review & editing: Daniel Martínez-Moreno, spherox
Guillermo Rus, Gema Jiménez, Patricia Gálvez- 10. Vinatier C, Guicheux J. Cartilage tissue engineering: from
Martín, Juan Antonio Marchal biomaterials and stem cells to osteoarthritis treatments. Ann
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Ethics approval and consent to participate doi: 10.1016/j.rehab.2016.03.002
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obtained from the patients. cartilage matrix synthesis in collagen sponge scaffolds by
using siRNA to stabilize chondrocytes phenotype cultured
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Not applicable doi: 10.1089/ten.TEC.2012.0508
12. Bentley G, Biant LC, Vijayan S, Macmull S, Skinner JA,
Availability of data Carrington RWJ. Minimum ten-year results of a prospective

The datasets used and/or analyzed during the current randomised study of autologous chondrocyte implantation
study are available from the corresponding authors upon versus mosaicplasty for symptomatic articular cartilage
lesions of the knee. J Bone Joint Surg Br. 2012;94(4):504-509.
reasonable request.
doi: 10.1302/0301-620X.94B4.27495
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