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Figure 3. Typical Fourier transform infrared spectrum of MAPLE-deposited rapamycin-PVP thin film
(red spectrum) and dropcast coating (black spectrum), respectively.
Figure 4. Reductions in proliferation (left) and cell viability (right) were observed in L929 fibroblasts
cultured on borosilicate glass coated with rapamycin using MAPLE (rapamycin-PVP) versus untreated
borosilicate glass (control). Values represent of x SD± N = 3 independent replicate experiments. Bars
with asterisks are significantly different from the negative control (P < 0.05).
borosilicate glass control. Alamar Blue and 4 Conclusions
PicoGreen experiments demonstrated reduced Highly uniform rapamycin-PVP thin films were
cell viability and proliferation, respectively, when successfully deposited onto the surfaces of
grown on MAPLE-deposited rapamycin-PVP silicon and borosilicate optical glass substrates
surfaces compared to borosilicate glass control using MAPLE. The antiproliferative properties
ones.
International Journal of Bioprinting (2020)–Volume 6, Issue 1 109
