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Wong, et al.
           may not be able to read the text or identify          Several  auxiliary  communication  aids are
           and  comprehend  important  information  on         available, including Braille embossers and Audible
           conventional printed medication labels . This       Prescription Labeling  Systems (APLS). Braille
                                                   [7]
           visual limitation puts them in the same or higher   embossers can print medication  information
           risk than the general population for drug-related   and  enable  information  accessibility  at  will .
                                                                                                            [11]
           problems associated with improper use of            However, only a small percentage of BVI patients
           medications , such as concomitant medication        can read Braille . Furthermore, pharmacists are
                       [8]
                                                                              [13]
           use and consuming wrong dosages . The               not formally trained to read the Braille printout,
                                                  [9]
           difficulties experienced by BVI patients are also   thus are unable to ensure information  accuracy.
           compounded by other issues, such as similar         Braille  printouts  are  also  often  bulky  and  large,
           container shapes and sizes, or being prescribed     thereby  challenging  the  ease  of  affixation  on
           with multiple  medications .  Studies have          medications . On the other hand, APLS aids rely
                                                                          [11]
                                        [6]
           reported that blind Americans have an average       on human voice recordings, where an electronic
           of 3.3 health conditions .  This is particularly    form of prescription  information  is stored in a
                                   [1]
           of concern for elderly BVI patients because         microchip  that  is  embedded  in  the  medication
           they tend to have more co-morbidities and more      label. BVI patients can then use a hand-held reader
           medications because of age.                         to decode the label information . However, this
                                                                                             [11]
             The most common approach that BVI patients        is not  scalable  as reading and  comprehension
           use to read medication labels is having someone     abilities  vary among  BVI patients . To  this
                                                                                                   [11]
           else (e.g., caregiver) read to them , which creates   end,  it is necessary  to  develop  an  auxiliary  aid
                                          [10]
           dependency  and undermines self-determination       that addresses the needs of BVI patients and the
           and well-being. This is especially so for individuals   limitations of existing aids.
           who  are  used  to  being  self-sufficient  before    Recently, additive  manufacturing,  commonly
           suffering  from  their  medical  condition.  They   known  as three-dimensional printing (3DP)
           may feel more diminished and vulnerable as they     technology has been used widely in various fields,
           play a less active role in managing their health .   such as manufacturing for product prototyping ,
                                                                                                            [14]
                                                        [11]
           Furthermore, communication challenges arise as      customization of hearing aids and dental crowns ,
                                                                                                            [15]
           information is transcribed from the pharmacist or   and manufacture of volumetric tactile symbols for
           physician to the patient through a third party . In   tactile maps to teach geography to BVI persons.
                                                      [7]
           addition,  patient  confidentiality  is  compromised   By harnessing the potential of 3DP technologies,
           for those who do not wish to have their  health     tactile  aids may be developed to provide BVI
           information  disclosed to others.  Their  rights to   patients  with important  information  regarding
           object to disclosure are diminished as they have    their medications through their sense of touch.
           no other meaningful alternative of reading the        Multiple 3DP technologies have been used for
           medication labels, other than relying on someone    biological and medical applications, for example,
           else .                                              stereolithography apparatus (SLA)  and inkjet
              [11]
             Other approaches  that  visually-impaired         printing [16,17] . SLA uses liquid  photopolymer
           patients use to manage their medications include    resins and laser to create 3D structures. Hou et al.
           the use of handheld magnifiers and reading glasses   utilized SLA to generate a simplified artificial skin
           to enlarge their  medication labels,  and relying   model useful for rapidly screening nanoparticles
           on  memory  to  remember instructions  provided     for their  transdermal  penetration  capacity .
                                                                                                            [18]
           during a face-to-face counseling session with their   Inkjet bioprinters deliver a controlled amount of
           health-care provider, of which the former method    bioink to the desired printing surface, forcing the
           is  inapplicable  for  the  blind . These  methods   content  to  flow  continuously  or  drop  out  from
                                       [12]
           present  risks for these  patients,  especially  those   the nozzle . Xu et al. created complex cellular
                                                                         [19]
           who  are prescribed with multiple  medications,     structures by inkjet printing of primary embryonic
           each with differing instructions.                   hippocampal and cortical neurons .
                                                                                               [20]
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