Page 46 - IJB-10-6

International

Journal of Bioprinting

REVIEW ARTICLE
The promising role of semi-solid extrusion

technology in custom drug formulation for
pediatric medicine

Thomas Cerveto , Lucas Denis 2,3 id , Maxime Stoops , Anna Lechanteur 4 id ,
2
1
Christine Jérôme 5 id , Julien Leenhardt 6,7,8 id , Stephen Flynn ,
9
Alvaro Goyanes 10,11,12 id , Roseline Mazet * , Maxime Annereau * ,
6 id
2 id
and Luc Choisnard 1 id
1 Grenoble Alpes University and Centre National de la Recherche Scientifique (CNRS; French
National Centre for Scientific Research), Département de Pharmacochimie Moléculaire (DPM;
Department of Molecular Pharmacochemistry), Unité Mixte de Recherche (UMR; Mixed Research
Unit), Grenoble, France
2 Clinical Pharmacy Department, Gustave Roussy Cancer Campus, Villejuif, France
3 Paris-Saclay University and CNRS, Institut Galien Paris-Saclay, UMR, Orsay, France
4 Laboratory of Pharmaceutical Technology and Biopharmacy, Center for Interdisciplinary Research
on Medicines (CIRM), University of Liège, Liège, Belgium
5 CESAM Research Unit, Center for Education and Research on Macromolecules (CERM), University
of Liège, Liège, Belgium
6 Pharmacy Department, Centre Hospitalier Universitaire (CHU; University Hospital Center)
Grenoble Alpes, Grenoble, France
7 Nuclear Medicine Department, CHU Grenoble Alpes, Grenoble, France
8 Grenoble Alpes University, Institut National de la Santé et de la Recherche Médicale (INSERM;
*Corresponding authors: National Institute of Health and Medical Research), Laboratoire de Recherche sur les Maladies
Roseline Mazet Cardiovasculaires (LRB; Cardiovascular Diseases Research Laboratory), UMR, Grenoble, France
(RMazet@chu-grenoble.fr)
9 Global Pharma Marketing service, Roquette Frères, Lestrem, France
Maxime Annereau
(Maxime.ANNEREAU@ 10 Departamento de Farmacología, Farmacia y Tecnología Farmacéutica, I+D Farma (GI-1645),
gustaveroussy.fr) Facultad de Farmacia, Instituto de Materiales (iMATUS) and Health Research Institute of Santiago
de Compostela (IDIS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain
Citation: Cerveto T, Denis L,
Stoops M, et al. The promising 11 Department of Pharmaceutics, UCL School of Pharmacy, University College London, Brunswick

role of semi-solid extrusion Square, London, UK
technology in custom drug 12 FABRX Ltd., Henwood House, Henwood, Ashford, Kent, UK
formulation for pediatric medicine.
Int J Bioprint. 2024;10(6):4063. (This article belongs to the Special Issue: Advanced Biomaterials for 3D Printing and Healthcare Application)
doi: 10.36922/ijb.4063
Received: June 27, 2024
Revised: August 6, 2024 Abstract
Accepted: August 7, 2024
Published Online: August 29, 2024 The long-standing issue of inadequate medicine formulations has been a focus of
regulatory bodies and pharmaceutical research, particularly in adapting medicines
Copyright: © 2024 Author(s).
This is an Open Access article for children’s unique requirements. The pediatric population presents diverse
distributed under the terms of the challenges in pharmacotherapy due to their varying age-related physiological
Creative Commons Attribution differences, and taste and dosage form preferences. Conventional formulations
License, permitting distribution,
and reproduction in any medium, often fail to meet these needs, leading to a high prevalence of off-label medication
provided the original work is use and modifications by caregivers, which can compromise drug efficacy and
properly cited. safety. The well-known challenges of managing children’s medication are similar to
Publisher’s Note: AccScience those in geriatrics, both of which require dose adjustments to accommodate the
Publishing remains neutral with patient’s pathophysiological characteristics and prevent deglutination problems.
regard to jurisdictional claims in
published maps and institutional This paper explores recent innovations in drug formulations, highlighting the shift
affiliations. from traditional liquid formulations to solid dosages through three-dimensional (3D)

Volume 10 Issue 6 (2024) 38 doi: 10.36922/ijb.4063