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RESEARCH ARTICLE

A Codispersed Nanosystem of Silver-anchored MoS
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Enhances Antibacterial and Antitumor Properties of

Selective Laser Sintered Scaffolds

Leliang Zheng 1,2,3 , Yancheng Zhong 1,2,3 , Tiantian He 1,2,3 , Shuping Peng 1,2,3 *, Liuyimei Yang *
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1 NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism of Hunan Cancer Hospital and
the Affiliated Cancer Hospital of Xiangya School of Medicine; School of basic Medical Science, Central South University,
Changsha, Hunan 410013, China
2 The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Xiangya Hospital,
Central South University, Changsha, Hunan China
3 Hunan Key Laboratory of Non Resolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya
Hospital, Central South University, Changsha, Hunan, China
4 Ganjiang Innovation Academy, Chinese Academy of Sciences, Ganzhou 341119, China

Abstract: Tumor recurrence and bacterial infection are common problems during bone repair and reconstruction after
bone tumor surgery. In this study, silver-anchored MoS nanosheets (Ag@PMoS ) were synthesized by in situ reduction,
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then a composite polymer scaffold (Ag@PMoS /PGA) with sustained antitumor and antibacterial activity was successfully
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constructed by selective laser sintering technique. In the Ag@PMoS nanostructures, silver nanoparticles (Ag NPs) were
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sandwiched between adjacent MoS nanosheets (MoS NSs), which restrained the restacking of the MoS NSs. In addition,
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the MoS NSs acted as steric hindrance layers, which prevented the aggregation of Ag NPs. More importantly, MoS NSs can
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provide a barrier layer for Ag NPs, hindering Ag NPs from reacting with the external solution to prevent its quick release.
The results showed that Ag@PMoS /PGA scaffolds have stronger photothermal effect and antitumor function. Meanwhile,
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the Ag@PMoS /PGA scaffolds also demonstrated slow control of silver ion (Ag ) release and more efficient long-term
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antibacterial ability. Besides, composite scaffolds have been proved to kill the MG-63 cells by inducing apoptosis and inhibit
bacterial proliferation by upregulating the level of bacterial reactive oxygen species. This kind of novel bifunctional implants
with antitumor and antibacterial properties provides better choice for the artificial bone transplantation after primary bone
tumor resection.
Keywords: Selective laser sintering; In situ growth; Photothermal therapy; Apoptosis; ROS
*Correspondence to: Shuping Peng, NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism of Hunan
Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine; School of basic Medical Science, Central South University,
Changsha, Hunan 410013, China; shuping@csu.edu.cn; Liuyimei Yang, Ganjiang Innovation Academy, Chinese Academy of Sciences, Ganzhou
341119, China; lymyang@gia.cas.cn
Received: March 14, 2022; Accepted: April 17, 2022; Published Online: June 3, 2022
Citation: Zheng L, Zhong Y, He T, et al., 2022, A Codispersed Nanosystem of Silver-anchored MoS Enhances Antibacterial and Antitumor
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Properties of Selective Laser Sintered Scaffolds. Int J Bioprint, 8(3):577. http://doi.org/10.18063/ijb.v8i43.577
1. Introduction combined with chemotherapy significantly improved the
[2]
Primary bone tumors such as osteosarcoma, survival rate of patients , some challenges such as tumor
chondrosarcoma, and Ewing’s sarcoma as well as bone recurrence from post-operative tumor residue, side effects
metastases such as lung cancer seriously threaten the from chemotherapy, and strong ability of tumor invasion
survival prognosis of patients . Although surgical treatment and metastasis still exist . In addition, bone grafts are
[1]
[3]
© 2022 Author(s). This is an Open-Access article distributed under the terms of the Creative Commons Attribution License, permitting distribution and
reproduction in any medium, provided the original work is properly cited.
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